Document Detail


Arterial and venous vessels are required for modulating developmental relocalization and laterality of the interrenal tissue in zebrafish.
MedLine Citation:
PMID:  20549735     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During zebrafish embryogenesis, the endothelium signals to emergent bilateral interrenal primordia to converge toward the midline, yet the merged interrenal tissue has been found to be situated lateral to the midline. We show in this study that bilateral interrenal tissue clusters fused at the central midline, before relocating laterally to be juxtaposed between the dorsal aorta and the posterior cardinal vein. In ets1b morphants where the midtrunk vasculature failed to assemble, various degrees of interrenal fusion defects were displayed, and the interrenal laterality was lost. As either arterial or venous endothelium was specifically reduced, the interrenal tissue was defective in its relocalization and laterality, yet remained closely associated with the malformed vasculature. Our results showed evidence to support that assembly of the axial artery and vein, and its resulting vascular topology at the midtrunk, is required for patterning relocalization and laterality of the interrenal tissue after the initial medial fusion.
Authors:
Chih-Wei Chou; Hsiao-Chu Hsu; Sue-Ing Quek; Woon-Khiong Chan; Yi-Wen Liu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  239     ISSN:  1097-0177     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-29     Completed Date:  2010-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1995-2004     Citation Subset:  IM    
Copyright Information:
(c) 2010 Wiley-Liss, Inc.
Affiliation:
Department of Life Science, Tunghai University, No. 181 Sec. 3 Taichung-Port Road, Taichung, Taiwan, R.O.C.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / embryology*
In Situ Hybridization
Microscopy, Confocal
Veins / embryology*
Zebrafish / embryology*

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