Document Detail


Arterial-venous concentration gradient as a potential source of error in pharmacokinetic studies. Plasma concentration differences of 6-chloro-2-pyridylmethyl nitrate on constant infusion to rats.
MedLine Citation:
PMID:  2763575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Plasma concentrations of 6-chloro-2-pyridylmethyl nitrate (CPMN) at different sampling sites in the circulation were determined during and after constant infusion in the rat. 2. An arterial-venous CPMN concentration gradient was found and characterized by the following trends. During CPMN infusion into the right atrium, plasma concentrations were higher in arterial (aortic arch) than venous (inferior vena cava) plasma. After cessation of infusion the venous plasma concentrations were significantly higher (P less than 0.05) than those in arterial samples. There was a low concentration gradient between the right atrium and the peripheral artery, but substantial difference between the peripheral artery and the vein. There was a 1.8-2.4 extraction ratio of CPMN across the arterial-venous bed.
Authors:
T Terada; K Ishibashi; T Tsuchiya; H Noguchi; T Mimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Xenobiotica; the fate of foreign compounds in biological systems     Volume:  19     ISSN:  0049-8254     ISO Abbreviation:  Xenobiotica     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-09-21     Completed Date:  1989-09-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1306665     Medline TA:  Xenobiotica     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  661-7     Citation Subset:  IM    
Affiliation:
Product Development Laboratories, Fujisawa Pharmaceutical Co. Ltd., Osaka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / physiology
Chromatography, Gas
Infusions, Intravenous
Male
Pyridines / administration & dosage,  blood,  pharmacokinetics*
Rats
Rats, Inbred Strains
Vasodilator Agents / pharmacokinetics*
Veins / physiology
Chemical
Reg. No./Substance:
0/Pyridines; 0/Vasodilator Agents; 90500-72-4/6-chloro-2-pyridylmethyl nitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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