Document Detail


Arterial and venous blood sampling in pharmacokinetic studies: propranolol in rabbits and dogs.
MedLine Citation:
PMID:  7268207     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Significant and persistent arterial-venous (A-V) plasma concentration differences of propranolol in unanesthetized rabbits and dogs following intravenous bolus injection or intravenous infusion were found. Both arterial and venous data were then subjected to extensive pharmacokinetic analyses utilizing standard procedures. Marked differences in calculated noncompartmental pharmacokinetic parameters such as the steady-state volume of distribution, absolute amount present in the body, and relative contribution of the terminal phase were obtained. The appropriateness of using venous propranolol plasma data for multicompartmental mammillary pharmacokinetic modeling analysis was discussed. The significance of the present study in pharmacokinetic and pharmacodynamic investigations of propranolol in humans remains to be explored.
Authors:
G Lam; W L Chiou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  33     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  33-48     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries
Blood Specimen Collection
Dogs
Infusions, Intra-Arterial
Infusions, Parenteral
Injections, Intravenous
Kinetics
Male
Propranolol / administration & dosage,  blood*
Rabbits
Veins
Chemical
Reg. No./Substance:
525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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