| Arterial transit time imaging with flow encoding arterial spin tagging (FEAST). | |
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MedLine Citation:
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PMID: 12939768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arterial spin labeling (ASL) perfusion imaging provides direct and absolute measurement of cerebral blood flow (CBF). Arterial transit time is a related physiological parameter reflecting the duration for the labeled spins to reach the brain region of interest. Most of the existing ASL approaches to assess arterial transit time rely on multiple measurements at various postlabeling delay times, and thus are vulnerable to motion artifact as well as computational error. We describe the use of flow encoding arterial spin tagging (FEAST) technique to measure tissue transit time, which can be derived from the ratio between the ASL signals measured with and without appropriate bipolar gradients. In the present study, we provided a theoretical framework and carried out an experimental validation during steady-state imaging. The global mean tissue transit time was approximately 1100 and 1400 ms for two conditions of bipolar gradients with specific encoding velocity (Venc) of 29 and 8 mm/sec, respectively. The mean tissue transit time measured within cerebral vascular territories was shortest in the deep middle cerebral artery (MCA) territory. Application of the FEAST technique in two patients with cerebrovascular disease demonstrated prolonged tissue transit times in the affected vascular territories which were consistent with results from other MR imaging modalities. |
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Authors:
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Jiongjiong Wang; David C Alsop; Hee Kwon Song; Joseph A Maldjian; Kathy Tang; Alana E Salvucci; John A Detre |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 50 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-08-26 Completed Date: 2004-01-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 599-607 Citation Subset: IM |
Copyright Information:
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Copyright 2003 Wiley-Liss, Inc. |
Affiliation:
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Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. jwang@rad.upenn.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Algorithms Arteries Blood Flow Velocity Cerebrovascular Circulation / physiology* Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging / methods* Male Spin Labels |
| Grant Support | |
ID/Acronym/Agency:
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DA015149/DA/NIDA NIH HHS; HD39621/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Spin Labels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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