Document Detail


Arterial thrombosis as clinical manifestation of congenital protein C deficiency.
MedLine Citation:
PMID:  2049465     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 49-year-old man was hospitalized for slight paresis of the upper left limb. Thrombosis of the right internal carotid artery was documented by arteriography and digital angiography, which showed evidence of an anastomotic blood flow. He went on anticoagulation treatment. Five years later, after an uneventful period, he was referred to our center for the occurrence of a superficial thrombophlebitis: diagnosis of congenital protein C deficiency was possible in the patient as well as in two of his relatives. Two other subjects with congenital protein C deficiency belonging to two different kindreds, whose illness was diagnosed in our center, suffered from myocardial infarction and TIA, respectively, as the only clinical manifestation; a fourth case, previously described, with recurrent superficial thrombophlebitis, suffered from a TIA when on treatment with stanozolol. These cases indicate that arterial thrombosis or TIA is not an uncommon event in congenital protein C deficiency, even in patients without other risk factors for arterial thrombosis.
Authors:
V De Stefano; G Leone; P Micalizzi; L Teofili; P G Falappa; G Pollari; B Bizzi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of hematology     Volume:  62     ISSN:  0939-5555     ISO Abbreviation:  Ann. Hematol.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-07-25     Completed Date:  1991-07-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  180-3     Citation Subset:  IM    
Affiliation:
Istituto di Semeiotica Medica, Università Cattolica del S. Cuore, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Carotid Artery Thrombosis / etiology*
Heterozygote
Humans
Ischemic Attack, Transient / etiology
Male
Middle Aged
Myocardial Infarction / etiology
Protein C / genetics
Protein C Deficiency*
Thrombophlebitis / etiology
Chemical
Reg. No./Substance:
0/Protein C

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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