Document Detail

Arterial thrombosis after intravenous infusion of oral bacterium in a rat model.
MedLine Citation:
PMID:  18411025     Owner:  NLM     Status:  MEDLINE    
Oral bacteria have been detected at atherosclerotic plaque, aneurysms, and thrombosed arteries in Buerger disease. We explored a possible relationship between the oral bacterium Porphyromonas gingivalis and arterial thrombosis at proximal and distal sites in rats. Eighteen rats underwent subcutaneous placement of an infusion pump connected to the jugular vein. The Pg infusion group received a continuous infusion of P. gingivalis for 2 weeks, and the controls received normal saline. At 2 and 4 weeks, specimens were obtained from the iliac, superficial, and below-knee arteries, which were studied pathologically and by polymerase chain reaction (PCR) analysis to detect P. gingivalis-specific DNA. The Pg infusion group had thrombosis in 33.3% at 2 weeks and in 55.6% at 4 weeks, but normal arterial wall structure was preserved without any features of infection. Positive PCR findings were recognized in 73.3% and 22.2% at 2 and 4 weeks, respectively. At 4 weeks, thrombosis was observed in a higher proportion, with the below-knee specimens having an especially high thrombus rate (83.3%). No control specimen had thrombosis or positive PCR results. Bacteremia due to the oral pathogen P. gingivalis may lead to thrombus formation in the peripheral arteries, especially in small-sized arteries.
Toshiya Kubota; Yoshinori Inoue; Takehisa Iwai; Nobuhisa Kurihara; Yi Huang; Makoto Umeda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-14
Journal Detail:
Title:  Annals of vascular surgery     Volume:  22     ISSN:  1615-5947     ISO Abbreviation:  Ann Vasc Surg     Publication Date:    2008 May-Jun
Date Detail:
Created Date:  2008-05-09     Completed Date:  2008-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703941     Medline TA:  Ann Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  412-6     Citation Subset:  IM    
Department of Vascular and Applied Surgery, Tokyo Medical and Dental University, Graduate School of Medicine and Dentistry, Tokyo, Japan.
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MeSH Terms
Arterial Occlusive Diseases / microbiology*,  pathology
Arteries / microbiology*,  pathology
Bacteroidaceae Infections / complications*,  microbiology,  pathology
DNA, Viral / metabolism
Disease Models, Animal
Iliac Artery / microbiology
Infusion Pumps, Implantable
Infusions, Intravenous
Mouth / microbiology*
Polymerase Chain Reaction
Porphyromonas gingivalis / genetics,  pathogenicity*
Rats, Wistar
Thrombosis / microbiology*,  pathology
Time Factors
Reg. No./Substance:
0/DNA, Viral

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