Document Detail

Arterial structure and function in end-stage renal disease.
MedLine Citation:
PMID:  18474176     Owner:  NLM     Status:  MEDLINE    
Cardiovascular disease is a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). Macrovascular disease develops rapidly in ESRD patients and is responsible for the high incidence of left ventricular hypertrophy, ischemic heart disease, cerebrovascular accidents, and peripheral artery diseases. Occlusive lesions due to atheromatous plaques frequently cause these complications; however, atherosclerosis represents only one form of structural response to metabolic and hemodynamic alterations interfering with the "natural" process of aging. The spectrum of arterial alterations in ESRD is broader, including large artery remodeling, changes in viscoelastic properties, and stiffening of arterial walls. Nonatheromatous remodeling principally changes the dampening function of arteries, characterized by stiffening of arterial walls and with deleterious effects on the left ventricle and coronary perfusion. The origin of arterial stiffening in ESRD patients is multifactorial, with extensive arterial calcifications as an important covariate.
Alain P Guérin; Bruno Pannier; Sylvain J Marchais; Gérard M London
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current hypertension reports     Volume:  10     ISSN:  1534-3111     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-05-13     Completed Date:  2008-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  107-11     Citation Subset:  IM    
Hôpital Manhès, 8 rue Roger Clavier, Fleury-Mérogis, 91712, France.
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MeSH Terms
Arteries / pathology*,  physiopathology*
Arteriosclerosis / pathology,  physiopathology
Atherosclerosis / pathology,  physiopathology
Cardiovascular Diseases / etiology,  pathology*,  physiopathology*
Disease Progression
Endothelium, Vascular / pathology,  physiopathology
Kidney Failure, Chronic / complications*,  pathology,  physiopathology

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