| Arterial structure and function and environmental exposure to cadmium. | |
| | |
MedLine Citation:
|
PMID: 17951338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: Few studies have addressed the effect of cadmium toxicity on arterial properties. METHODS: We investigated the possible association of 24 h urinary cadmium excretion (an index of lifetime exposure) with measures of arterial function in a randomly selected population sample (n = 557) from two rural areas with low and high environmental exposure to cadmium. RESULTS: 24 h urinary cadmium excretion was significantly higher in the high compared with the low exposure group (p<0.001). Even though systolic (p = 0.42), diastolic (p = 0.14) and mean arterial pressure (p = 0.68) did not differ between the high and low exposure groups, aortic pulse wave velocity (p = 0.008), brachial pulse pressure (p = 0.026) and femoral pulse pressure (p = 0.008) were significantly lower in the high exposure group. Additionally, femoral distensibility (p<0.001) and compliance (p = 0.001) were significantly higher with high exposure. Across quartiles of 24 h urinary cadmium excretion (adjusted for sex and age), brachial (p for trend = 0.015) and femoral (p for trend = 0.018) pulse pressure significantly decreased and femoral distensibility (p for trend = 0.008) and compliance (p for trend = 0.007) significantly increased with higher cadmium excretion. After full adjustment, the partial regression coefficients confirmed these associations. Pulse wave velocity (beta = -0.79+/-0.27; p = 0.004) and carotid (beta = -4.20+/-1.51; p = 0.006), brachial (beta = -5.43+/-1.41; p = 0.001) and femoral (beta = -4.72+/-1.74; p = 0.007) pulse pressures correlated negatively, whereas femoral compliance (beta = 0.11+/-0.05; p = 0.016) and distensibility (beta = 1.70+/-0.70; p = 0.014) correlated positively with cadmium excretion. CONCLUSION: Increased cadmium body burden is associated with lower aortic pulse wave velocity, lower pulse pressure throughout the arterial system, and higher femoral distensibility. |
| | |
Authors:
|
R Schutte; T Nawrot; T Richart; L Thijs; H A Roels; L M Van Bortel; H Struijker-Boudier; J A Staessen |
Related Documents
:
|
12214258 - Evolution of ambulatory measurement of blood pressure and parameters of arterial stiffn... 20330098 - A new acoustic lens design for electromagnetic shock wave lithotripters. 20683338 - Long-term reduction in aortic stiffness: a 5.3-year follow-up in routine clinical pract... 20408258 - An independent relationship between muscle sympathetic nerve activity and pulse wave ve... 2569838 - Cardiovascular effects produced by l-glutamate stimulation of the lateral hypothalamic ... 10724638 - Reducing adverse effects of inhaled fenoterol through optimization of the aerosol formu... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-10-19 |
Journal Detail:
|
Title: Occupational and environmental medicine Volume: 65 ISSN: 1470-7926 ISO Abbreviation: Occup Environ Med Publication Date: 2008 Jun |
Date Detail:
|
Created Date: 2008-05-19 Completed Date: 2008-06-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9422759 Medline TA: Occup Environ Med Country: England |
Other Details:
|
Languages: eng Pagination: 412-9 Citation Subset: IM |
Affiliation:
|
Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Arteries / drug effects*, physiology Blood Flow Velocity / drug effects Blood Pressure / drug effects Body Burden Brachial Artery / drug effects, physiology Cadmium / toxicity*, urine Carotid Artery, Common / drug effects, physiology Compliance / drug effects Environmental Exposure / analysis* Female Femoral Artery / drug effects, physiology Humans Male Middle Aged Pulsatile Flow / drug effects Rural Health Vasodilation / drug effects |
| Chemical | |
Reg. No./Substance:
|
7440-43-9/Cadmium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Exposures and reported symptoms associated with occupational deployment to the Buncefield fuel depot...
Next Document: Incidence of respiratory sensitisation and allergy to enzymes among employees in an enzyme producing...