| Arterial stiffness and pulse-pressure amplification in overweight/obese african- american adolescents: relation with higher systolic and pulse pressure. | |
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MedLine Citation:
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PMID: 23382323 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND Obesity is associated with a higher systolic blood pressure (BP) and pulse pressure (PP) in African-American youths, increasing their risk for developing hypertension. However, it is unknown whether arterial stiffness and wave reflection are associated with a higher systolic BP and PP or with smaller PP amplification in overweight/obese (OW/OB) African-American adolescents. METHODS We measured carotid-femoral pulse wave velocity (CF-PWV), carotid-radial PWV (CR-PWV), the augmentation index (AIx) adjusted to a heart rate of 75 bpm (AI75), the augmentation pressure (AugP), PP amplification, and body composition in 227 healthy African-American adolescents (age, 16.9±0.2 years; 54% male). RESULTS Adolescents who were OW/OB (n = 86, body mass index (BMI) ≥ 85th percentile) demonstrated 5%-6%, 13%-16%, and 2.5% higher aortic and brachial systolic BP, brachial and aortic PP, and mean arterial pressure (MAP), respectively (all P < 0.05), than adolescents of normal-weight (NW, n = 141, BMI < 85th percentile). The OW/OB adolescents had a 7% higher CF-PWV, 5% lower CR-PWV, and 3.5% lower PP amplification than the NW group (all P < 0.05), but no differences in AI75 or AugP. In the entire cohort after adjustment for age, sex, heart rate, height, and MAP, CF-PWV was positively correlated, and CR-PWV and PP amplification were negatively correlated, with total and abdominal/hip adiposity. Additionally, CF-PWV, AI75, and AugP were positively correlated with MAP and negatively correlated with PP amplification. CR-PWV, AI75, and AugP were negatively correlated with brachial and aortic PP. CONCLUSIONS Higher aortic stiffness is associated with smaller PP amplification with increasing adiposity in African-American adolescents. Whether a reduction in PP amplification predicts increased CVD risk in obese African-American adolescents requires further study. |
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Authors:
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Gary L Pierce; Haidong Zhu; Katherine Darracott; Itoro Edet; Jigar Bhagatwala; Ying Huang; Yanbin Dong |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of hypertension Volume: 26 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-02-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 20-6 Citation Subset: IM |
Affiliation:
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Department of Health and Human Physiology, University of Iowa, Iowa City, IA; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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