Document Detail

Arterial stiffness and osteoporosis in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  17363772     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of cardiovascular events and osteoporosis. Increased arterial stiffness is an independent predictor of cardiovascular disease.
OBJECTIVES: We tested the hypothesis that patients with COPD would have increased arterial stiffness, which would be associated with osteoporosis and systemic inflammation.
METHODS: We studied 75 clinically stable patients with a range of severity of airway obstruction and 42 healthy smoker or ex-smoker control subjects, free of cardiovascular disease. All subjects underwent spirometry, measurement of aortic pulse wave velocity (PWV) and augmentation index, dual-energy X-ray absorptiometry, and blood sampling for inflammatory mediators.
MEASUREMENTS AND MAIN RESULTS: Mean (SD) aortic PWV was greater in patients, 11.4 (2.7) m/s, than in control subjects, 8.95 (1.7) m/s, p < 0.0001. Inflammatory mediators and augmentation index were also greater in patients. Patients with osteoporosis at the hip had a greater aortic PWV, 13.1 (1.8) m/s, than those without, 11.2 (2.7) m/s, p < 0.05. In patients, aortic PWV was related to age (r = 0.63, p < 0.0001) and log(10) IL-6 (r = 0.31, p < 0.01), and inversely to FEV(1) (r = -0.34, p < 0.01). The strongest predictors of aortic PWV in all subjects were age (p < 0.0001), percent predicted FEV(1) (p < 0.05), mean arterial pressure (p < 0.05), and log(10) IL-6 (p < 0.05).
CONCLUSIONS: Increased arterial stiffness was related to the severity of airflow obstruction and may be a factor in the excess risk for cardiovascular disease in COPD. The increased aortic PWV in patients with osteoporosis and the association with systemic inflammation suggest that age-related bone and vascular changes occur prematurely in COPD.
Ramsey Sabit; Charlotte E Bolton; Peter H Edwards; Rebecca J Pettit; William D Evans; Carmel M McEniery; Ian B Wilkinson; John R Cockcroft; Dennis J Shale
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-15
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  175     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-04     Completed Date:  2007-07-19     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1259-65     Citation Subset:  AIM; IM    
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MeSH Terms
Absorptiometry, Photon
Aging, Premature / epidemiology,  physiopathology
Body Composition
Cardiovascular Diseases / epidemiology,  physiopathology
Inflammation / epidemiology*,  physiopathology
Middle Aged
Osteoporosis / epidemiology*,  physiopathology
Pulmonary Disease, Chronic Obstructive / epidemiology*,  physiopathology
Respiratory Function Tests
Risk Factors
Grant Support
FS/07/001/21990//British Heart Foundation
Comment In:
Am J Respir Crit Care Med. 2008 Apr 15;177(8):929; author reply 929-30   [PMID:  18390966 ]
Am J Respir Crit Care Med. 2007 Jun 15;175(12):1217-8   [PMID:  17545454 ]

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