Document Detail

Arterial stiffness and orthostatic blood pressure changes in untreated and treated hypertensive subjects.
MedLine Citation:
PMID:  20409918     Owner:  NLM     Status:  In-Data-Review    
Carotid-femoral pulse wave velocity (PWV), an integrated marker of segmental aortic stiffness, was recently proposed as one of the underlying mechanisms inducing orthostatic hypotension in the elderly with marked arterial rigidity. We examined the relationship between PWV (Complior; Colson, Paris, France) and orthostatic blood pressure (BP) changes, measured repeatedly, over a wide range of age and arterial stiffness. Sixty-nine hypertensive subjects (age, 37 to 76 years; 39 untreated and 30 treated) were studied. BP, in both sitting and erect position, was measured at two occasions a few weeks apart, and in between PWV was assessed by means of pulse wave analysis. In untreated hypertensive subjects, the orthostatic alterations in systolic, but not in diastolic blood pressure (DBP), were inversely related to PWV, independently from age, gender, mean BP, and diabetes mellitus. The greater the aortic stiffness the larger was the systolic blood pressure (SBP) decrease during upraises. On the contrary, no such association was found between PWV and orthostatic changes of BP in treated hypertensive subjects. These results suggest the presence of a pathophysiological association between arterial stiffening and BP postural changes. Antihypertensive drug treatment, as well as other factors that have not been evaluated in the present study, might have modulated this association. However, it might be argued that a causal association between arterial stiffness - disturbed baroreflex sensitivity - postural BP changes, even in subjects without pronounced vascular aging or orthostatic hypotension, is implied.
Athanase D Protogerou; George S Stergiou; Panagiota Lourida; Apostolos Achimastos
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Publication Detail:
Type:  Journal Article     Date:  2008-06-11
Journal Detail:
Title:  Journal of the American Society of Hypertension : JASH     Volume:  2     ISSN:  1933-1711     ISO Abbreviation:  J Am Soc Hypertens     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2010-04-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101312518     Medline TA:  J Am Soc Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  372-7     Citation Subset:  -    
Hypertension Center, 3rd University Department of Medicine, Sotiria Hospital, University of Athens, Athens, Greece.
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