Document Detail

Arterial stiffness is increased in patients with inflammatory bowel disease.
MedLine Citation:
PMID:  22796713     Owner:  NLM     Status:  Publisher    
BACKGROUND AND AIMS:: Recent studies have reported early atherosclerosis in patients with inflammatory bowel disease (IBD). In these patients, the chronic low-grade inflammation may predispose to vascular remodelling and arterial stiffening. We aimed at studying arterial stiffness in IBD patients. METHODS:: Thirty-two IBD patients without cardiovascular risk factors and 32 matched controls were enrolled (age 19-49 years). SphygmoCor device (AtCor Medical, Sydney, Australia) was used to measure carotid-femoral and carotid-radial (muscular artery) pulse wave velocity (PWV), augmentation index and central blood pressure. RESULTS:: Carotid-femoral PWV was higher in IBD patients than in controls (6.6 ± 1.4 vs. 6.0 ± 0.8 m/s, respectively, P < 0.05), as well as carotid-radial PWV (8.5 ± 1.2 vs. 7.2 ± 1.0 m/s, P < 0.001). Central pulse pressure was higher in IBD than in controls (32 ± 6 vs. 28 ± 7 mmHg, P < 0.05). Aging was an important determinant of carotid-femoral PWV in both groups and carotid-radial PWV only in IBD patients. In fully adjusted model performed in both groups of patients considered as a whole, age was positively associated with carotid-femoral PWV [R = 0.10; +0.05 m/s per 1 year of aging, 95% confidence interval (CI) 0.01-0.08 m/s, P < 0.05], as well as IBD (R = 0.10; +0.72 m/s if IBD present, 95% CI 0.19-1.26 m/s, P < 0.05). In IBD patients, carotid-radial PWV was positively associated with the disease duration (R = 0.20; +0.11 m/s per 1 year of aging, 95% CI 0.03-0.19 m/s, P < 0.05). CONCLUSION:: Arterial stiffness is increased in patients with IBD independently of conventional cardiovascular risk factors.
Luca Zanoli; Mariarita Cannavò; Stefania Rastelli; Luigi Di Pino; Ines Monte; Marcella Di Gangi; Pierre Boutouyrie; Gaetano Inserra; Stephane Laurent; Pietro Castellino
Related Documents :
22405023 - A 3-year follow-up study on the risk of stroke among patients with conjunctival haemorr...
22693633 - Macrophage migration inhibitory factor is enhanced in acute coronary syndromes and is a...
21242043 - Unenhanced versus multiphase mdct in patients with hematuria, flank pain, and a negativ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-12
Journal Detail:
Title:  Journal of hypertension     Volume:  -     ISSN:  1473-5598     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
aDepartment of Internal Medicine, University of Catania, Catania, Italy bDepartment of Pharmacology, Hôpital Européen Georges Pompidou, Assistance Publique, Hôpitaux de Paris, INSERM U970, Paris Descartes University, Paris, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cost-effectiveness and budget impact analyses of a long-term hypertension detection and control prog...
Next Document:  L-Carnitine prevents the development of ventricular fibrosis and heart failure with preserved ejecti...