Document Detail

Arterial stiffness in type 1 diabetes mellitus is aggravated by autoimmune thyroid disease.
MedLine Citation:
PMID:  16218044     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of our study was to measure arterial stiffness in patients with Type 1 diabetes mellitus, its contributing factors and its relation to macrovascular arterial changes. MATERIALS AND METHODS: Thirty-one female Type 1 diabetic patients were studied; 11 had concomitant autoimmune thyroid disease although euthyroid during the study period. Stiffness was studied using applanation tonometry and pulse wave analysis for evaluation of systolic arterial pressure augmentation secondary to arterial stiffening and early wave reflection. Results were compared to 24 healthy individuals. In all patients, endothelium-related flow-mediated dilation (FMD) of the brachial artery and intima-media thickness (IMT) of the carotid artery were measured. RESULTS: Augmentation pressure (AP) and augmentation index (AI) were higher in Type 1 diabetic patients suggesting stiffer arteries compared to controls (AP: 5.8 +/- 3.6 vs 2.8 +/- 2.2 mmHg, p < 0.001; and AI:18.3 +/- 9 vs 11.1 +/- 8.8%, p = 0.004). The subgroup of diabetic patients with autoimmune thyroid disease presented stiffer arteries than those without (AP: 6.5 +/- 2.9 vs 5.5 +/- 3.9 mmHg, p < 0.05; and AI: 21.3 +/- 5.4 vs 16.7 +/- 10.3%, p < 0.05), though the two groups did not differ statistically by means of age, disease duration, hemoglobin A1c (HbA1c), lipid levels, FMD and IMT. In multiple regression analysis, variables independently associated to AI in the diabetes group were: age (p = 0.028), IMT of the carotid artery bifurcation (p = 0.045), disease duration (p = 0.031) and autoimmune thyroid disease (p = 0.015). No correlation was observed between AI and metabolic control, blood pressure, microalbuminuria, presence of retinopathy and endothelial function (FMD). CONCLUSIONS: Women with Type 1 diabetes have increased arterial stiffness, which indicates macroangiopathy. An independent correlation between these indices and carotid IMT was observed. Concomitant autoimmune thyroid disease seems to aggravate arterial compliance in these patients, a finding that merits further investigation.
D Tryfonopoulos; E Anastasiou; A Protogerou; T Papaioannou; K Lily; A Dagre; E Souvatzoglou; C Papamichael; M Alevizaki; J Lekakis
Related Documents :
10454234 - Myoclonic encephalopathy and diabetes mellitus in a boy.
20960264 - Japanese cases of acute onset diabetic ketosis without acidosis in the absence of gluta...
21858504 - No association of vitamin d intake or 25-hydroxyvitamin d levels in childhood with risk...
20805634 - Trajectories of anti-islet autoantibodies before development of type 1 diabetes in inte...
7029504 - Severe hypertriglyceridaemia responding to insulin and nicotinic acid therapy.
11978634 - Insulin expression levels in the thymus modulate insulin-specific autoreactive t-cell t...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  28     ISSN:  0391-4097     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:    2005 Jul-Aug
Date Detail:
Created Date:  2005-10-12     Completed Date:  2006-01-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  616-22     Citation Subset:  IM    
Department of Clinical Therapeutics, Alexandra University Hospital, Athens, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arteries / pathology*
Blood Pressure / physiology
Carotid Arteries / pathology
Diabetes Complications / pathology*
Diabetes Mellitus, Type 1 / immunology*,  pathology*,  physiopathology
Thyroiditis, Autoimmune / immunology,  pathology*,  physiopathology
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Adiponectin values are unchanged during pregnancy in rats.
Next Document:  Effects of raloxifene on body fat distribution and lipid profile in healthy post-menopausal women.