Document Detail


Arterial stiffness in mild-to-moderate CKD.
MedLine Citation:
PMID:  19608701     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Whether arterial stiffness correlates with mild-to-moderate CKD and albuminuria in the community is unclear. We studied the association between arterial stiffness and mild-to-moderate CKD and albuminuria in the Framingham Heart Study. CKD was present in 6.7% (181 of 2682) of participants and microalbuminuria was present in 8.2% (479 of 5818). The measures of arterial stiffness were the carotid femoral pulse wave velocity, forward pressure wave amplitude, central pulse pressure, augmentation pressure, augmentation index, and mean arterial pressure. In cross-sectional analyses, arterial stiffness did not associate with CKD (defined by estimated GFR <60 ml/min/1.73 m(2)) in either age- and gender-adjusted or multivariable-adjusted linear regression models. Carotid femoral pulse wave velocity associated with both urinary albumin-to-creatinine ratio and microalbuminuria (P < 0.0001 after multivariable adjustment). In longitudinal analyses, we used logistic regression models to examine the associations between baseline arterial stiffness measures (exposure variables) and incident CKD or microalbuminuria (n = 1675 for CKD analyses and n = 1252 for microalbuminuria analyses). Baseline arterial measures did not associate with incident CKD or incident microalbuminuria. In summary, arterial stiffness correlates with albuminuria but not with mild-to-moderate CKD.
Authors:
Ashish Upadhyay; Shih-Jen Hwang; Gary F Mitchell; Ramachandran S Vasan; Joseph A Vita; Plamen I Stantchev; James B Meigs; Martin G Larson; Daniel Levy; Emelia J Benjamin; Caroline S Fox
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-07-16
Journal Detail:
Title:  Journal of the American Society of Nephrology : JASN     Volume:  20     ISSN:  1533-3450     ISO Abbreviation:  J. Am. Soc. Nephrol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-01     Completed Date:  2009-10-02     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  9013836     Medline TA:  J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2044-53     Citation Subset:  IM    
Affiliation:
Renal Section, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Albuminuria / epidemiology*,  physiopathology
Blood Flow Velocity
Cardiovascular Diseases / epidemiology*,  physiopathology
Carotid Arteries / physiopathology
Female
Femoral Artery / physiopathology
Glomerular Filtration Rate
Humans
Incidence
Kidney / physiology
Logistic Models
Male
Middle Aged
Multivariate Analysis
Pulsatile Flow
Renal Insufficiency, Chronic / epidemiology*,  physiopathology
Severity of Illness Index*
Grant Support
ID/Acronym/Agency:
2-K24-HL04334/HL/NHLBI NIH HHS; K24-DK080140/DK/NIDDK NIH HHS; N01-HC-25195/HC/NHLBI NIH HHS; R01-AG028321/AG/NIA NIH HHS; R01-HL-077477/HL/NHLBI NIH HHS; R01-HL076784/HL/NHLBI NIH HHS; R01-HL080124/HL/NHLBI NIH HHS; R01-HL60040/HL/NHLBI NIH HHS; R01-HL70100/HL/NHLBI NIH HHS
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