Document Detail

Arterial stiffness, hydrochlorothiazide and converting enzyme inhibition in essential hypertension.
MedLine Citation:
PMID:  8867559     Owner:  NLM     Status:  MEDLINE    
In a randomized double blind study, the arterial changes produced either by hydrochlorothiazide plus amiloride (Group I), or by hydrochlorothiazide plus captopril (Group II) were investigated in two territories of the arterial tree, the common carotid artery and the terminal aorta. Arterial echo-tracking techniques of high resolution and applanation tonometry were used to evaluate non-invasively the indices of arterial stiffness and carotid wave reflections. In Group I and II, there was a similar significant decrease in brachial blood pressure (BP) and carotid diastolic diameter and an increase in aortic compliance and distensibility. Groups I and II differed significantly in aortic diastolic diameter which decreased in Group I but not in Group II, and in carotid wave reflections which were modified in Group II but not in Group I. Thus, captopril associated with hydrochlorothiazide resulted in a shift in the carotid arterial reflection wave from systole to diastole with no reduction in the aortic diastolic dimension. For similar BP reduction, the combination of hydrochlorothiazide and amiloride had no significant effect on the carotid reflection wave, but caused a significant reduction in the aortic diastolic diameter. These intergroup differences were related to the presence or absence of converting enzyme inhibition.
A Bénétos; A Laflèche; R Asmar; S Gautier; A Safar; M E Safar
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of human hypertension     Volume:  10     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-12-04     Completed Date:  1996-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  IM    
Department of Internal Médecine and INSERM U337, Broussais Hospital, Paris, France.
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MeSH Terms
Amiloride / administration & dosage,  therapeutic use*
Angiotensin-Converting Enzyme Inhibitors / administration & dosage,  therapeutic use*
Blood Pressure / drug effects
Captopril / administration & dosage,  therapeutic use*
Diuretics / administration & dosage,  therapeutic use*
Double-Blind Method
Drug Therapy, Combination
Hydrochlorothiazide / administration & dosage,  therapeutic use*
Hypertension / drug therapy*,  physiopathology
Middle Aged
Sodium Chloride Symporter Inhibitors / administration & dosage,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Diuretics; 0/Sodium Chloride Symporter Inhibitors; 2609-46-3/Amiloride; 58-93-5/Hydrochlorothiazide; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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