Document Detail


Arterial stiffness and hormone replacement use in healthy postmenopausal women.
MedLine Citation:
PMID:  9754139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Arterial stiffness has been shown to be positively related to cardiovascular disease risk. Little, however, is known about the influence of hormone replacement use on arterial stiffness in females. METHODS: Arterial pulse wave velocity (PWV) and carotid augmentation index (AI, applanation tonometry) were measured in 34 healthy postmenopausal women, including users (n = 18) and nonusers (n = 16) of hormone replacement. RESULTS: There were no significant group differences in any of the physical characteristics including resting blood pressure. None of the measures of arterial stiffness differed between user and nonusers of hormone replacement. CONCLUSIONS: The present cross-sectional study indicates that reduced arterial stiffness does not appear to be a likely mechanism contributing to the lower incidence of cardiovascular disease in postmenopausal women taking hormone replacement.
Authors:
H Tanaka; C A DeSouza; D R Seals
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  53     ISSN:  1079-5006     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-10-15     Completed Date:  1998-10-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  M344-6     Citation Subset:  AIM; IM    
Affiliation:
Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, University of Colorado at Boulder, Denver, USA. tanakah@colorado.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Arteries / drug effects,  physiology*
Blood Pressure / drug effects
Cross-Sectional Studies
Estrogen Replacement Therapy*
Female
Humans
Middle Aged
Postmenopause
Grant Support
ID/Acronym/Agency:
AG-06537/AG/NIA NIH HHS; AG-13038/AG/NIA NIH HHS; HL-39966/HL/NHLBI NIH HHS

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