Document Detail

Arterial stiffness, cognitive decline, and risk of dementia: the Rotterdam study.
MedLine Citation:
PMID:  17272780     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Arterial stiffness is associated with an increased risk of myocardial infarction and stroke, independent of classical vascular risk factors. Vascular factors and stroke are associated with cognitive function and dementia. We examined whether arterial stiffness was independently associated with cognitive function and dementia. METHODS: The present study was based on the Rotterdam Study, a prospective population-based cohort study ongoing since 1990. During the third examination (1997-1999) arterial stiffness was measured by assessment of pulse wave velocity and carotid distensibility. Cognitive function was assessed during the third and fourth examination (2002-2004) with a neuropsychological test battery. We used linear and logistic regression to estimate the association of arterial stiffness with cognitive function and cognitive decline. From the third examination until January 1, 2005, we identified 156 incident dementia cases. Cox proportional hazard models were used to estimate the association between arterial stiffness and the risk of dementia. RESULTS: After adjustment for cardiovascular risk factors we found an association of increased pulse wave velocity with poorer performance on the Stroop test (adjusted beta-coefficient [95% confidence interval] 1.13 [0.26 to 1.99] per standard deviation increase in pulse wave velocity) but not with performance on other cognitive tests. No associations were found between measures of arterial stiffness and cognitive decline or risk of dementia after adjustment for cardiovascular factors. CONCLUSIONS: We did not identify arterial stiffness as an independent risk factor of cognitive decline or risk of dementia.
Mariëlle M F Poels; Marieke van Oijen; Francesco U S Mattace-Raso; Albert Hofman; Peter J Koudstaal; Jacqueline C M Witteman; Monique M B Breteler
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-01
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  38     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-27     Completed Date:  2007-03-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  888-92     Citation Subset:  IM    
Department of Epidemiology & Biostatistics, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
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MeSH Terms
Aged, 80 and over
Blood Flow Velocity / physiology
Carotid Artery, Common / physiology*
Cognition Disorders / epidemiology*,  physiopathology*,  psychology
Cohort Studies
Cross-Sectional Studies
Dementia / epidemiology*,  physiopathology*,  psychology
Middle Aged
Neuropsychological Tests
Prospective Studies
Risk Factors
Vascular Resistance / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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