| Arterial stiffness, central blood pressure and body size in health and disease. | |
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MedLine Citation:
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PMID: 21487397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Body size is associated with increased brachial systolic blood pressure (SBP) and aortic stiffness. The aims of this study were to determine the relationships between central SBP and body size (determined by body mass index (BMI), waist circumference and waist/hip ratio) in health and disease. We also sought to determine if aortic stiffness was correlated with body size, independent of BP. METHODS: BMI, brachial BP and estimated central SBP (by SphygmoCor and radial P2) were recorded in controls (n=228), patients with diabetes (n=211), coronary artery disease (n=184) and end-stage kidney disease (n=68). Additional measures of waist circumference and arterial stiffness (aortic and brachial pulse wave velocity (PWV)) were recorded in a subgroup of 75 controls (aged 51 ± 12 years) who were carefully screened for factors affecting vascular function. RESULTS: BMI was associated with brachial (r=0.30; P<0.001) and central SBP (r=0.29; P<0.001) in the 228 controls, but not the patient populations (r<0.13; P>0.15 for all comparisons). In the control subgroup, waist circumference was also significantly correlated with brachial SBP (r=0.29; P=0.01), but not central SBP (r=0.22; P=0.07). Independent predictors of aortic PWV in the control subgroup were brachial SBP (β=0.43; P<0.001), age (β=0.37; P<0.001), waist circumference (β=0.39; P=0.02) and female sex (β=-0.24; P=0.03), but not BMI. CONCLUSION: In health, there are parallel increases in central and brachial SBP as BMI increases, but these relationships are not observed in the presence of chronic disease. Moreover, BP is a stronger correlate of arterial stiffness than body size. |
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Authors:
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O O Kolade; T M O'Moore-Sullivan; M Stowasser; J S Coombes; R G Fassett; T H Marwick; J E Sharman |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2011-04-12 |
Journal Detail:
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Title: International journal of obesity (2005) Volume: 36 ISSN: 1476-5497 ISO Abbreviation: Int J Obes (Lond) Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-10 Completed Date: 2012-03-01 Revised Date: 2013-03-25 |
Medline Journal Info:
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Nlm Unique ID: 101256108 Medline TA: Int J Obes (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 93-9 Citation Subset: IM |
Affiliation:
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The University of Queensland, School of Human Movement Studies, Brisbane, Queensland, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity Blood Pressure* Body Mass Index* Brachial Artery / physiopathology Cardiovascular Diseases / blood, epidemiology, physiopathology* Chronic Disease Cross-Sectional Studies Diabetes Mellitus, Type 2 / blood, epidemiology, physiopathology* Echocardiography Female Humans Kidney Failure, Chronic / blood, epidemiology, physiopathology* Male Manometry Middle Aged Predictive Value of Tests Pulsatile Flow Risk Factors Sphygmomanometers Vascular Stiffness* Waist Circumference Waist-Hip Ratio |
| Comments/Corrections | |
Comment In:
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Int J Obes (Lond). 2013 Feb;37(2):320-1
[PMID:
22450849
]
Int J Obes (Lond). 2013 Feb;37(2):320 [PMID: 22450851 ] |
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