| Arterial stiffness, but not endothelium-dependent vasodilation, is related to a low Ankle-Brachial index. | |
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MedLine Citation:
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PMID: 21078066 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Arterial compliance and endothelium-dependent vasodilation are two characteristics of the vessel wall. In the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study we studied the relationships between arterial compliance and endothelium-dependent vasodilation versus the Ankle-Brachial index (ABI), a clinically used index of peripheral artery disease. Methods: In the population-based PIVUS study (all aged 70), arterial compliance was determined by ultrasound as the distensibility of the carotid artery and the stroke volume to pulse pressure (SV/PP) ratio by echocardiography, while endothelium-dependent vasodilation was assessed by the invasive forearm technique with acetylcholine (EDV) and brachial artery ultrasound (FMD) in 519 subjects in whom the Ankle-Brachial index was investigated. Results: After adjustments for gender and Framingham risk score, distensibility in the carotid artery and the SV/PP ratio were significantly reduced in subjects with a reduced ABI (<0·9) in both legs (n = 15, P = 0·0006 and P = 0·0003, respectively). Endothelium-dependent vasodilation was not significantly related to a reduced ABI. Conclusion: A reduced arterial compliance, but not endothelium-dependent vasodilation, was related to a low ABI in both legs after adjustment for major risk factors, suggesting that atherosclerosis in the leg arteries is associated with arterial compliance also in other parts of the vasculature. |
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Authors:
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Lars Lind |
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Publication Detail:
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Type: Journal Article Date: 2010-11-15 |
Journal Detail:
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Title: Clinical physiology and functional imaging Volume: 31 ISSN: 1475-097X ISO Abbreviation: Clin Physiol Funct Imaging Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137604 Medline TA: Clin Physiol Funct Imaging Country: England |
Other Details:
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Languages: eng Pagination: 182-7 Citation Subset: IM |
Copyright Information:
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© 2010 The Author. Clinical Physiology and Functional Imaging © 2010 Scandinavian Society of Clinical Physiology and Nuclear Medicine. |
Affiliation:
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Department of Medicine, Uppsala University Hospital, Uppsala, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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