| Arterial stiffness: a brief review. | |
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MedLine Citation:
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PMID: 20802505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Physical stiffening of the large arteries is the central paradigm of vascular aging. Indeed, stiffening in the larger central arterial system, such as the aortic tree, significantly contributes to cardiovascular diseases in older individuals and is positively associated with systolic hypertension, coronary artery disease, stroke, heart failure and atrial fibrillation, which are the leading causes of mortality in the developed countries and also in the developing world as estimated in 2010 by World Health Organizations. Thus, better, less invasive and more accurate measures of arterial stiffness have been developed, which prove useful as diagnostic indices, pathophysiological markers and predictive indicators of disease. This article presents a review of the structural determinants of vascular stiffening, its pathophysiologic determinants and its implications for vascular research and medicine. A critical discussion of new techniques for assessing vascular stiffness is also presented. |
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Authors:
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Najeeb A Shirwany; Ming-hui Zou |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-08-30 |
Journal Detail:
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Title: Acta pharmacologica Sinica Volume: 31 ISSN: 1745-7254 ISO Abbreviation: Acta Pharmacol. Sin. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-05 Completed Date: 2011-02-17 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 100956087 Medline TA: Acta Pharmacol Sin Country: United States |
Other Details:
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Languages: eng Pagination: 1267-76 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, 73104, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology Animals Arteries / metabolism, physiopathology* Cardiovascular Diseases / genetics, metabolism, physiopathology* Diagnostic Techniques, Cardiovascular Diet Elasticity* Endothelium, Vascular / physiopathology Glucose / physiology Humans Insulin / physiology Neurosecretory Systems / physiopathology Risk Factors Vascular Resistance* |
| Grant Support | |
ID/Acronym/Agency:
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HL074399/HL/NHLBI NIH HHS; HL079584/HL/NHLBI NIH HHS; HL080499/HL/NHLBI NIH HHS; HL089920/HL/NHLBI NIH HHS; HL096032/HL/NHLBI NIH HHS; R01 HL074399-05/HL/NHLBI NIH HHS; R01 HL074399-06/HL/NHLBI NIH HHS; R01 HL074399-07/HL/NHLBI NIH HHS; R01 HL074399-08/HL/NHLBI NIH HHS; R01 HL079584-07/HL/NHLBI NIH HHS; R01 HL079584-08/HL/NHLBI NIH HHS; R01 HL079584-09/HL/NHLBI NIH HHS; R01 HL080499-04/HL/NHLBI NIH HHS; R01 HL080499-05/HL/NHLBI NIH HHS; R01 HL089920-03/HL/NHLBI NIH HHS; R01 HL089920-04/HL/NHLBI NIH HHS; R01 HL096032-02/HL/NHLBI NIH HHS; R01 HL096032-03/HL/NHLBI NIH HHS; R01 HL096032-04/HL/NHLBI NIH HHS; R01 HL105157-01/HL/NHLBI NIH HHS; R01 HL105157-02/HL/NHLBI NIH HHS; R01 HL105157-03/HL/NHLBI NIH HHS; R01 HL110488-02/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Insulin; 50-99-7/Glucose |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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