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Arterial stiffness as a cause of cognitive decline and dementia: A systematic review and meta-analysis.
MedLine Citation:
PMID:  22151013     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background.  Although arterial stiffness has recently been confirmed as a predictor of cardiovascular disease, the association between arterial stiffness and cognitive decline is less clear. Aim.  We performed a systematic review and meta-analysis to examine the evidence for large artery stiffness as a cause of cognitive decline and dementia. Method.  Electronic databases were systematically searched until September 2011 for studies reporting on the longitudinal relationship between any validated measure of large artery stiffness and cognitive decline or dementia. Meta-analysis was performed on 4 studies investigating the association between aortic pulse wave velocity and a decline in Mini Mental State Examination (MMSE) scores. Results.  Six relevant longitudinal studies were located, conducted over an average of 5 years follow-up. Arterial stiffness was predictive of cognitive decline in 5/6 studies. In meta-analysis, higher aortic stiffness predicted lower MMSE scores (β= -0.03, 95% CI: -0.06 to 0.01, N = 3,947), although studies were not all homogenous and statistical heterogeneity was present (I(2) = 71.9%, p= 0.01). Removal of one study with a relatively younger cohort and lower median aortic stiffness found higher aortic stiffness to significantly predict cognitive decline (β= - 0.04, 95% CI: -0.07 to -0.01, N = 3,687) without evidence of heterogeneity (I(2) = 9.5%, p= 0.33). There was little research investigating the effects of aortic stiffness on the development of dementia. Conclusion.  Aortic stiffness was found to predict cognitive decline in both qualitative review and quantitative analysis.
Authors:
Matthew P Pase; Annie Herbert; Natalie A Grima; Andrew Pipingas; Michael F O'Rourke
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-8
Journal Detail:
Title:  Internal medicine journal     Volume:  -     ISSN:  1445-5994     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101092952     Medline TA:  Intern Med J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Sydney South West Area Health Service. Journal compilation © 2011 Royal Australasian College of Physicians.
Affiliation:
Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia, 3122. Department of Pharmacology and INSERM U970, Hôpital Européen Georges Pompidou and Faculté de Médecine, Université René Descartes, Paris, France Faculty of Medicine, Nursing and Health Sciences, School of Psychology and Psychiatry, Monash University, Clayton, Australia, 3168. St Vincent's Clinic, Victor Chang Cardiac Research Institute and University of New South Wales, Sydney, Darlinghurst, Australia, 2010.
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