Document Detail


Arterial stiffness after successful renal transplantation.
MedLine Citation:
PMID:  18790249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiovascular disease is a major barrier to the long-term survival of transplant recipients. The aim of this study was to determine whether successful renal transplantation improves the arterial stiffness resulting from chronic renal failure. This study involved a group of 9 recipients (23-56 years) who underwent successful renal transplantation at our clinic. The brachial-ankle pulse wave velocity and--intima-media thickness of the bilateral common carotid arteries were measured in each patient before and 1 year after successful renal transplantation. One year after renal transplantation, the 9 patients showed a mean serum creatinine level of 1.41 mg/dL. Assessment of arterial stiffness in this group revealed that the mean brachial-ankle pulse wave velocity was reduced after renal transplantation, but there was no reduction in the mean intima-media thickness of the bilateral common carotid arteries. There was a significant correlation between the variance ratios of pulse wave velocity and median blood pressure. The more effective blood pressure control provided by renal transplantation may functionally improve arterial stiffness. However, organic arterial stiffness remained unchanged 1 year after transplantation.
Authors:
T Nishioka; T Akiyama; K Nose; H Koike
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  40     ISSN:  0041-1345     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-15     Completed Date:  2008-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2405-8     Citation Subset:  IM    
Affiliation:
Department of Urology, Sakai Hospital, Kinki University School of Medicine, Osaka, Japan. tsukasan@sakai.med.kndai.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Carotid Arteries / immunology,  pathology*,  ultrasonography
Cyclosporine / therapeutic use
Female
Humans
Immunosuppressive Agents / therapeutic use
Kidney Diseases / classification,  surgery
Kidney Transplantation / adverse effects*,  immunology
Living Donors
Male
Middle Aged
Pulse
Tacrolimus / therapeutic use
Tunica Intima / immunology,  pathology*
Tunica Media / immunology,  pathology*
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 109581-93-3/Tacrolimus; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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