| Arterial spin labeling perfusion MRI at multiple delay times: a correlative study with H(2)(15)O positron emission tomography in patients with symptomatic carotid artery occlusion. | |
| | |
MedLine Citation:
|
PMID: 19809464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) with image acquisition at multiple inversion times is a noninvasive ASL technique able to compensate for spatial heterogeneities in transit times caused by collateral blood flow in patients with severe stenosis of the cerebropetal blood vessels. Our aim was to compare ASL-MRI and H(2)(15)O positron emission tomography (PET), the gold standard for cerebral blood flow (CBF) assessment, in patients with a symptomatic internal carotid artery (ICA) occlusion. Fourteen patients (63+/-14 years) with a symptomatic ICA occlusion underwent both ASL-MRI and H(2)(15)O PET. The ASL-MRI was performed using a pulsed STAR labeling technique at multiple inversion times within 7 days of the PET. The CBF was measured in the gray-matter of the anterior, middle and posterior cerebral artery, and white-matter. Both PET and ASL-MRI showed a significantly decreased CBF in the gray-matter of the middle cerebral artery in the hemisphere ipsilateral to the ICA occlusion. The average gray-matter CBF measured with ASL-MRI (71.8+/-4.3 mL/min/100 g) was higher (P<0.01) than measured with H(2)(15)O PET (43.1+/-1.0 mL/min/100 g). In conclusion, ASL-MRI at multiple TIs is capable of depicting areas of regions with low CBF in patients with an occlusion of the ICA, although a systematic overestimation of CBF relative to H(2)(15)O PET was noted. |
| | |
Authors:
|
Reinoud P H Bokkers; Jochem P Bremmer; Bart N M van Berckel; Adriaan A Lammertsma; Jeroen Hendrikse; Josien P W Pluim; L Jaap Kappelle; Ronald Boellaard; Catharina J M Klijn |
Related Documents
:
|
9291384 - Cerebral fat embolism studied by magnetic resonance imaging, transcranial doppler sonog... 10096334 - Correlation of regional cerebral blood flow measured by stable xenon ct and perfusion mri. 3471364 - A simplified method of xenon-enhanced ct for regional cerebral blood flow (rcbf) measur... 6600754 - Superimposition of krypton-81m single photon emission ct and x-ray ct images for cerebr... 12439574 - Mr cisternography after intrathecal gd-dtpa application. 7946444 - The value of three-dimensional radiotherapy planning in advanced carcinoma of the urina... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-07 |
Journal Detail:
|
Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 30 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2010-01-04 Completed Date: 2010-02-03 Revised Date: 2011-07-20 |
Medline Journal Info:
|
Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 222-9 Citation Subset: IM |
Affiliation:
|
Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands. r.p.h.bokkers@umcutrecht.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Carotid Stenosis / radionuclide imaging* Cerebrovascular Circulation / physiology Cerebrovascular Disorders / radionuclide imaging Deuterium / diagnostic use Female Humans Magnetic Resonance Imaging Male Middle Aged Oxygen Radioisotopes / diagnostic use Positron-Emission Tomography Risk Factors Spin Labels |
| Chemical | |
Reg. No./Substance:
|
0/Oxygen Radioisotopes; 0/Spin Labels; 7782-39-0/Deuterium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cilostazol, a phosphodiesterase inhibitor, attenuates photothrombotic focal ischemic brain injury in...
Next Document: The impact of erythropoietin on short-term changes in phosphorylation of brain protein kinases in a ...