| Arterial spin-labeled MRI study of migraine attacks treated with rizatriptan. | |
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MedLine Citation:
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PMID: 20411294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spin-tag perfusion imaging is an MRI method that quantitatively measures cerebral blood flow. Compared with conventional perfusion techniques, advantages of this arterial spin-labeling (ASL) include repeatability and the avoidance of intravenous contrast administration. In the present study, we performed an analysis of 3T high-field MRI examinations utilizing ASL perfusion during migraine attacks. A 32-year-old male patient was studied in three situations: during migraine attack within 1 h post-onset, 30 min after oral administration of rizatriptan 10 mg, and attack-free period. Normalized ASL images acquired during migraine attack showed significant relative hypoperfusion in the bilateral median thalamic areas including hypothalamus and significant relative hyperperfusion in the frontal cortex compared to images acquired during the migraine-free state. When normalized ASL images acquired 30 min after treatment were compared with those acquired during the attack, relative improvement of perfusion in the bilateral median thalamic areas including hypothalamus was observed. Hypothalamus and its surrounding areas may participate in the pathogenesis in migraine attack. |
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Authors:
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Yuji Kato; Nobuo Araki; Hiroshi Matsuda; Yasuo Ito; Chihiro Suzuki |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-04-22 |
Journal Detail:
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Title: The journal of headache and pain Volume: 11 ISSN: 1129-2377 ISO Abbreviation: J Headache Pain Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-10 Completed Date: 2010-08-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100940562 Medline TA: J Headache Pain Country: Italy |
Other Details:
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Languages: eng Pagination: 255-8 Citation Subset: IM |
Affiliation:
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Department of Neurology and Cerebrovascular Medicine, Saitama International Medical Center, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama 350-1298, Japan. yujik@saitama-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cerebral Arteries / drug effects, physiopathology Cerebrovascular Circulation / drug effects*, physiology Cerebrovascular Disorders / drug therapy, physiopathology Functional Laterality / physiology Humans Hyperemia / drug therapy, physiopathology Hypothalamus / blood supply, drug effects, physiopathology* Magnetic Resonance Imaging / methods* Male Migraine Disorders / diagnosis, drug therapy*, physiopathology* Prefrontal Cortex / blood supply, drug effects, physiopathology Serotonin Agonists / pharmacology, therapeutic use Thalamus / blood supply, drug effects, physiopathology Time Factors Treatment Outcome Triazoles / pharmacology*, therapeutic use Tryptamines / pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Serotonin Agonists; 0/Triazoles; 0/Tryptamines; 145202-66-0/rizatriptan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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