| Arterial response during cold pressor test in borderline hypertension. | |
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MedLine Citation:
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PMID: 9683427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We observed previously that sympathetic activation produced by lower body negative pressure increases pulse-pressure amplification with little change in mean pressure. Whether the cold pressor test (CPT) might produce a similar hemodynamic pattern has been ignored. Ten subjects with borderline hypertension and ten age- and sex-matched normotensive controls were compared to investigate carotid-brachial pulse-pressure amplification (aplanation tonometry) and changes in brachial and carotid distensibility (echotracking technique) before and during CPT. The maneuver markedly increased blood pressure without a change in heart rate. Pulse-pressure amplification tended to disappear as a consequence of a higher increase in carotid than in brachial pulse pressure, due to an earlier return of wave reflections at the carotid site. CPT caused a significant decrease in carotid and brachial distensibility. Both results were more pronounced in controls than in borderline hypertensives. Thus CPT reduces pulse-pressure amplification. In humans, this change may greatly influence the calculation of arterial distensibility, although this point is usually minimized in animal experiments. Furthermore, in young subjects, sympathetic stimulus may induce different arterial responses, depending on the mechanism involved: reflex or global nonspecific stimulus. |
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Authors:
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A B Lafleche; B M Pannier; B Laloux; M E Safar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of physiology Volume: 275 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-09-16 Completed Date: 1998-09-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H409-15 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Institut National de la Santé et de la Recherche Médicale (U337), Broussais Hospital, 75014 Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure* Brachial Artery / physiology, physiopathology Carotid Arteries / physiology, physiopathology Cold Temperature / diagnostic use* Diastole Female Heart Rate Humans Hypertension / physiopathology* Male Middle Aged Pulse Reference Values Systole Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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