Document Detail


Arterial reservoir-excess pressure and ventricular work.
MedLine Citation:
PMID:  22367750     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study is based on the hypothesis that the pressure within the arterial network can be usefully decomposed as the sum of a reservoir pressure and an excess pressure. The reservoir pressure waveform is defined to be the same in each vessel but delayed by the wave travel time from the root of the aorta. Using calculus of variations and mass conservation, which relates the flow and rates of change of pressure in the vessels, we show that the reservoir pressure waveform minimises the ventricular hydraulic work for any physiologically or clinically reasonable ejection waveform and arterial properties, i.e. vessel compliances and terminal resistances. We conclude that the excess pressure determines the excess work done by the ventricle, which may have clinically important implications.
Authors:
Kim H Parker; Jordi Alastruey; Guy-Bart Stan
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-26
Journal Detail:
Title:  Medical & biological engineering & computing     Volume:  -     ISSN:  1741-0444     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704869     Medline TA:  Med Biol Eng Comput     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Bioengineering, Imperial College, London, SW7 2AZ, UK, k.parker@imperial.ac.uk.
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