Document Detail


Arterial regeneration over polydioxanone prostheses in the rabbit.
MedLine Citation:
PMID:  3107517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We analyzed histologic, ultrastructural, and functional characteristics of rabbit aortic conduits regenerated over absorbable polydioxanone prostheses. Twenty-eight polydioxanone-elicited prosthesis/tissue complexes harvested two weeks to 12 months following implantation were analyzed grossly; photographed; sectioned for light, scanning, and transmission electron microscopy; and studied for compliance, bursting strength, and prostacyclin and thromboxane metabolite contents. No aortic-related deaths or hemorrhages occurred. Smooth regenerated conduits without stenoses were seen in 27 of 28 specimens, with one small aneurysm. Transprosthetic myofibroblast migration and proliferation paralleled the kinetics of macrophage-mediated prosthetic dissolution, which was consequently delayed compared with polyglycolic acid prostheses. Confluent endothelial-like luminal surfaces were present after two weeks. Progressive inner capsular thickening ended after three months at 420 micron. Ex vivo compliance curves resembled arterial elasticity. Regenerated tissue withstood 1200 mm Hg of systolic pressure, and 6-keto-prostaglandin F1 alpha to thromboxane B2 ratios did not differ from normal control specimens.
Authors:
H P Greisler; J Ellinger; T H Schwarcz; J Golan; R M Raymond; D U Kim
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of surgery (Chicago, Ill. : 1960)     Volume:  122     ISSN:  0004-0010     ISO Abbreviation:  Arch Surg     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-06-19     Completed Date:  1987-06-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9716528     Medline TA:  Arch Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  715-21     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
6-Ketoprostaglandin F1 alpha / metabolism
Animals
Biological Availability
Blood Vessel Prosthesis*
Female
Polydioxanone
Polyesters*
Rabbits
Regeneration*
Renal Artery / metabolism,  physiology*,  ultrastructure
Surface Properties
Tensile Strength
Thromboxane B2 / metabolism
Grant Support
ID/Acronym/Agency:
7 RO1 HL 32340-02/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Polyesters; 31621-87-1/Polydioxanone; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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