Document Detail

Arterial pulse wave velocity as a marker of poor cognitive function in an elderly community-dwelling population.
MedLine Citation:
PMID:  15972613     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Knowledge about potentially modifiable risk factors for cognitive decline is limited at this time. The aim of this study was to determine the cross-sectional relationship between a low level of cognitive function and brachial-ankle pulse wave velocity (baPWV) in a community-dwelling elderly population. METHODS: The study population included 352 community-dwelling Japanese persons ages 70 years and older who participated in a comprehensive health examination in April 2003. None had any history of cardiovascular disease. In addition to conventional medical examinations such as blood pressure and routine blood analyses, cognitive function was tested using the Mini-Mental State Examination (MMSE), and baPWV was determined using a recently developed noninvasive and automatic arterial waveform analyzer (AT-Form). This measure, with well-established validity and reproducibility, reflects both central and peripheral arterial flow. A multivariate logistic regression model tested the possible association between poor cognitive function (an MMSE score < 24) and baPWV. RESULTS: Poor cognitive function was independently associated with the middle tertile of baPWV (odds ratio [OR] = 9.66, 95% confidence interval [CI] = 1.15 to 80.93), age (1-year increment; OR = 1.12, 95% CI = 1.04 to 1.22), and the highest tertile of pulse pressure (OR = 4.70, 95% CI = 1.08 to 20.48) even after multivariate adjustment of data for the effects of age, educational level, and hemodynamic and metabolic antecedents of atherosclerosis. CONCLUSIONS: A high baPWV may be a potent risk factor for poor cognitive function in an elderly community-dwelling population, and this effect is independent of another marker of arterial stiffness: pulse pressure.
Yoshinori Fujiwara; Paulo H M Chaves; Ryutaro Takahashi; Hidenori Amano; Hiroto Yoshida; Shu Kumagai; Koji Fujita; Dou Gui Wang; Shoji Shinkai
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  60     ISSN:  1079-5006     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-06-23     Completed Date:  2005-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  607-12     Citation Subset:  AIM; IM    
Community Health Research Group, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.
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MeSH Terms
Aged, 80 and over
Ankle / blood supply
Biological Markers / analysis
Brachial Artery / physiopathology*
Cognition Disorders / diagnosis*,  epidemiology
Cohort Studies
Cross-Sectional Studies
Geriatric Assessment
Logistic Models
Multivariate Analysis
Plethysmography / instrumentation
Pulsatile Flow / physiology*
Residence Characteristics
Sensitivity and Specificity
Severity of Illness Index
Reg. No./Substance:
0/Biological Markers

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