Document Detail

Arterial pulse pressure and vasopressin release in humans during lower body negative pressure.
MedLine Citation:
PMID:  8498590     Owner:  NLM     Status:  MEDLINE    
The hypothesis was tested that narrowing of arterial pulse pressure (PP) is a determinant of arginine vasopressin (AVP) release in humans. Six normal males completed a two-step lower body negative pressure (LBNP) protocol of -20 and -50 mmHg, respectively, for 10 min each. None of these subjects experienced presyncopal symptoms. Arterial plasma AVP and plasma renin activity (PRA) (at 2-min intervals) only increased subsequent to a decrease in PP (invasive brachial arterial measurements) and stroke volume (ultrasound Doppler technique, n = 4). Simultaneously, mean arterial pressure did not change. A selective decrease in central venous pressure and left atrial diameter (echocardiography, n = 4) at LBNP of -20 mmHg did not affect AVP or PRA, whereas arterial plasma norepinephrine increased (n = 4). During LBNP, significant (P < 0.05) intraindividual linear correlations were observed between log(AVP) and PP in four of the subjects with r values from -0.75 to -0.99 and between log(PRA) and PP in all six subjects with r values from -0.89 to -0.98. In conclusion, these results are in compliance with the hypothesis that narrowing of PP in humans during central hypovolemia is a determinant of AVP and renin release.
P Norsk; P Ellegaard; R Videbaek; C Stadeager; F Jessen; L B Johansen; M S Kristensen; M Kamegai; J Warberg; N J Christensen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  264     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-21     Completed Date:  1993-06-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1024-30     Citation Subset:  IM; S    
Danish Aerospace Medical Centre of Research, Rigshospitalet, Copenhagen.
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MeSH Terms
Arginine Vasopressin / blood*
Arteries / physiology*
Blood Pressure*
Cardiovascular Physiological Phenomena
Endocrine Glands / physiology
Lower Body Negative Pressure*
Osmolar Concentration
Reg. No./Substance:
113-79-1/Arginine Vasopressin

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