| ARTERIAL PRESSURE OSCILLATIONS ARE NOT ASSOCIATED WITH MUSCLE SYMPATHETIC NERVE ACTIVITY IN INDIVIDUALS EXPOSED TO CENTRAL HYPOVOLAEMIA. | |
| | |
MedLine Citation:
|
PMID: 21930599 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The spectral power of low frequency oscillations of systolic arterial pressure (SAP(LF)) has been used as a non-invasive surrogate of muscle sympathetic nerve activity (MSNA) in both experimental and clinical situations. For SAP(LF) to be used in this way, a relationship must exist between SAP(LF) and MSNA within individuals during sympathetic activation. Using progressive central hypovolaemia to induce sympathetic activation, we hypothesised that SAP(LF) would correlate with MSNA in all subjects. ECG, beat-by-beat arterial pressure and MSNA were recorded in humans (n=20) during a progressive lower body negative pressure (LBNP) protocol designed to cause presyncope in all subjects. Arterial pressure oscillations were assessed in the low frequency (LF; 0.04-0.15 Hz) domain using a Fourier transform. For the entire group, SAP(LF), MSNA burst frequency, and total MSNA increased during LBNP. Values for coefficients of determination (r(2)) describing the linear associations of SAPLF with MSNA burst frequency and total MSNA were 0.73 and 0.84, but rose to 0.89 and .98 when curvilinear fits were used, indicating that the relationship is curvilinear rather than linear. Associations between SAP(LF) and MSNA within each individual subject, however, varied widely for both MSNA burst frequency and total MSNA, whether derived by linear (r(2) range, 1.7 x 10-6 to 0.99) or polynomial (r(2) range, 0.09 to 1.0) regression analysis. Similar results were obtained when relationships between low frequency oscillations in diastolic arterial pressure and MSNA were evaluated. These results do not support the use of SAP(LF) as a non-invasive measure of sympathetic outflow for individual subjects during sympathetic activation. |
| | |
Authors:
|
Kathy L Ryan; Caroline A Rickards; Carmen Hinojosa-Laborde; William H Cooke; Victor A Convertino |
Related Documents
:
|
12201929 - Renal water and sodium handling during gradated unilateral ureter obstruction. 15854149 - Mechanisms mediating pressure natriuresis: what we know and what we need to find out. 7573479 - Frequency domain of renal autoregulation in the conscious dog. 16817749 - Effects of ramipril on renal function during progressive overpacing-induced heart failu... 2514429 - Alteration of vascular thromboxane in rats with subtotal renal ablation. 7900839 - Pressure dependency of canine intrarenal blood flow within the range of autoregulation. 7817049 - Segmental pulmonary vascular resistances during oleic acid lung injury in rabbits. 3389319 - Calcium supplementation: effect on blood pressure and urinary mineral excretion in norm... 10685909 - Respiratory adaptations to running-water microhabitats in mayfly larvae epeorus sylvico... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-19 |
Journal Detail:
|
Title: The Journal of physiology Volume: - ISSN: 1469-7793 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0266262 Medline TA: J Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
US Army Institute of Surgical Research; |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prior Endurance Exercise Prevents Postprandial Lipemia-Induced Increases in Reactive Oxygen Species ...
Next Document: Gap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in th...