Document Detail


Arterial pressure control after chronic carotid sinus denervation.
MedLine Citation:
PMID:  3177680     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examines the control of arterial blood pressure in conscious, instrumented dogs with atrioventricular block before and greater than or equal to 9 days after carotid sinus baroreceptor denervation. Strength of reflex control of blood pressure was quantitated by measuring the changes in peripheral resistance and atrial rate after square wave changes in cardiac output. Surprisingly, nine or more days after carotid denervation, the strength of baroreflex control of peripheral resistance and atrial rate were not different (P greater than 0.05) from the values before denervation. This was not due to a change in the base-line levels of arterial pressure, atrial rate, cardiac output, or peripheral resistance. Bilateral vagal block after carotid denervation removed reflex effects from remaining baroreceptors and virtually eliminated changes in peripheral resistance in response to changes in arterial pressure. Therefore, the compensatory responses observed after carotid denervation were mediated by the remaining baroreceptors. Thus, after chronic carotid sinus denervation, there is no decrease in the strength of baroreflex control of peripheral resistance or heart rate.
Authors:
D S O'Leary; A M Scher
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  255     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-11-09     Completed Date:  1988-11-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H910-6     Citation Subset:  IM    
Affiliation:
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle 98195.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / physiology*
Blood Pressure*
Cardiac Output
Carotid Sinus / innervation*
Denervation*
Dogs
Heart Rate
Muscle, Smooth, Vascular / physiology
Pressoreceptors / physiology
Reference Values
Vagus Nerve / physiology
Ventricular Function
Grant Support
ID/Acronym/Agency:
HL-07090-1/HL/NHLBI NIH HHS; HL-16910/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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