Document Detail

Arterial pressure after chronic reductions in suprarenal aortic flow in fetal lambs.
MedLine Citation:
PMID:  3310664     Owner:  NLM     Status:  MEDLINE    
Experiments were performed on 13 fetal lambs of 126 days gestational age. Seven days after surgery, suprarenal aortic blood flow was reduced to 70% of control with an inflatable occluder for a period of at least 4 days. This produced an almost constant aortic pressure difference of 35 mmHg across the occluder. Plasma renin activity (PRA) rose in the next hour from 6 to 42 (P less than 0.01) but decreased to a level that was statistically insignificantly above normal by the next day. PRA as a function of lower body arterial blood pressure showed rapid adaptation. Upper body arterial blood pressure was statistically significantly elevated by 5 mmHg within 5 min and continued to rise while plasma renin activity was falling. Femoral artery blood pressure dropped immediately but returned to near normal within 1 h and remained there. The long-term upper body hypertension was irreversible with a 30-min infusion of saralasin. Subrenal aortic flow reduction caused none of these changes. We conclude that the fetal kidneys can regulate arterial blood pressure upward but that the long-term effect does not depend solely on a direct vasoconstrictive action of angiotensin.
D F Anderson; C M Parks; J J Faber
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  253     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-11-19     Completed Date:  1987-11-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H838-44     Citation Subset:  IM    
Department of Physiology, Oregon Health Sciences University, Portland 97201.
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MeSH Terms
Aorta / embryology*,  physiology
Blood Gas Analysis
Blood Pressure*
Heart Rate
Regional Blood Flow / drug effects
Renal Artery / physiology
Renin / blood
Saralasin / pharmacology
Grant Support
Reg. No./Substance:
34273-10-4/Saralasin; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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