| Arterial pressure after chronic reductions in suprarenal aortic flow in fetal lambs. | |
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MedLine Citation:
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PMID: 3310664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experiments were performed on 13 fetal lambs of 126 days gestational age. Seven days after surgery, suprarenal aortic blood flow was reduced to 70% of control with an inflatable occluder for a period of at least 4 days. This produced an almost constant aortic pressure difference of 35 mmHg across the occluder. Plasma renin activity (PRA) rose in the next hour from 6 to 42 ng.ml-1.h-1 (P less than 0.01) but decreased to a level that was statistically insignificantly above normal by the next day. PRA as a function of lower body arterial blood pressure showed rapid adaptation. Upper body arterial blood pressure was statistically significantly elevated by 5 mmHg within 5 min and continued to rise while plasma renin activity was falling. Femoral artery blood pressure dropped immediately but returned to near normal within 1 h and remained there. The long-term upper body hypertension was irreversible with a 30-min infusion of saralasin. Subrenal aortic flow reduction caused none of these changes. We conclude that the fetal kidneys can regulate arterial blood pressure upward but that the long-term effect does not depend solely on a direct vasoconstrictive action of angiotensin. |
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Authors:
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D F Anderson; C M Parks; J J Faber |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 253 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1987 Oct |
Date Detail:
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Created Date: 1987-11-19 Completed Date: 1987-11-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H838-44 Citation Subset: IM |
Affiliation:
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Department of Physiology, Oregon Health Sciences University, Portland 97201. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / embryology*, physiology Blood Gas Analysis Blood Pressure* Constriction Female Heart Rate Pregnancy Regional Blood Flow / drug effects Renal Artery / physiology Renin / blood Saralasin / pharmacology Sheep |
| Grant Support | |
ID/Acronym/Agency:
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HD-10034/HD/NICHD NIH HHS; S07 RR05412/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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34273-10-4/Saralasin; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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