Document Detail

Arterial oxygen saturation and hemoglobin mass in postmenopausal untrained and trained altitude residents.
MedLine Citation:
PMID:  18081505     Owner:  NLM     Status:  MEDLINE    
Because of lacking ventilatory stimulation by sex hormones in postmenopausal women (PW), one might expect a lowered arterial oxygen saturation (S(O(2))) in hypoxia and therefore a stronger erythropoietic reaction than in young women (YW). Nine untrained (UTRPW) and 11 trained (TRPW) postmenopausal altitude residents (2600 m) were compared to 16 untrained (UTRYW) and 16 trained young women (TRYW) to check this hypothesis and to study the combined response to hypoxia and training. S(O(2)) was decreased in PW (89.2% +/- 2.2 vs. 93.6 +/- 0.7% in YW, p < 0.01). Hb mass, however, was similar in UT (UTRYW: 9.2 +/- 0.9 g/kg(1), UTRPW: 8.7 +/- 1.0 g/kg). But if body fat rise with age was excluded by relation to fat-free mass, Hb mass was increased in UTRPW (+1.2 g/kg, p < 0.05) compared to UTRYW. Training caused a similar rise of Hb mass in PW and YW (0.3 g/kg per mL/kg x min(1) rise in V(O(2peak))). There was no difference in erythropoietin among the groups. Ferritin was higher in PW than YW. The results show that female hormones and fitness level have to be considered in studies on erythropoiesis at altitude. The role of erythropoietin during chronic hypoxia still has to be clarified.
Edgar Cristancho; Orlando Reyes; Mauricio Serrato; María Mercedes Mora; Joel Alberto Rojas; Yohan Robinson; Dieter Böning
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  High altitude medicine & biology     Volume:  8     ISSN:  1527-0297     ISO Abbreviation:  High Alt. Med. Biol.     Publication Date:  2007  
Date Detail:
Created Date:  2007-12-17     Completed Date:  2008-03-11     Revised Date:  2009-07-07    
Medline Journal Info:
Nlm Unique ID:  100901183     Medline TA:  High Alt Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  296-306     Citation Subset:  IM; S    
Institute of Sports Medicine, Charité, University Medicine Berlin.
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MeSH Terms
Acclimatization / physiology*
Blood Volume / physiology
Hemoglobins / analysis*
Middle Aged
Oxygen / blood
Oxygen Consumption / physiology*
Physical Fitness / physiology*
Reticulocyte Count
Reg. No./Substance:
0/Hemoglobins; 7782-44-7/Oxygen
Erratum In:
High Alt Med Biol. 2009 Spring;10(1):105

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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