Document Detail


Arterial oxygen saturation during ascending to altitude under various conditions: lessons from the field.
MedLine Citation:
PMID:  17996494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When hypoxia increases during ascending in the mountains, ventilatory control and the related oxygenation may be challenged. The pre-treatment by intermittent hypoxia will elevate ventilation and offset hypoxemia and acetazolamide may inhibit peripheral chemosensitivity and act through central mechanisms. To study these effects in the field, one well-trained male mountaineer performed four ascents from low (1300m) to higher altitude (2600m): (1) under control conditions, (2) after intermittent hypoxia, (3) after pre-treatment with acetazolamide, and (4) after intermittent hypoxia+acetazolamide. When ascending under control conditions a cascading decrease of arterial oxygen saturation (SaO(2)) has been observed probably because of the alternating dominance of peripheral and central mechanisms of ventilatory control. While the pre-treatment with intermittent hypoxia prolonged the constant SaO(2) periods, the intake of acetazolamide eliminated this respiratory periodicity. Oxygen desaturation was best prevented by acetazolamide which was also associated with faster ascent times compared to control conditions.
Authors:
Martin Burtscher
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Publication Detail:
Type:  Journal Article     Date:  2007-11-08
Journal Detail:
Title:  Journal of science and medicine in sport / Sports Medicine Australia     Volume:  11     ISSN:  1440-2440     ISO Abbreviation:  J Sci Med Sport     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-28     Completed Date:  2009-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812598     Medline TA:  J Sci Med Sport     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  535-7     Citation Subset:  IM    
Affiliation:
Department of Sport Science, Medical Section, University of Innsbruck, Austria. Martin.Burtscher@uibk.ac.at
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MeSH Terms
Descriptor/Qualifier:
Acetazolamide
Altitude*
Anoxia / physiopathology,  prevention & control
Arteries / metabolism*
Exercise Test
Humans
Male
Middle Aged
Mountaineering
Oxygen Consumption*
Chemical
Reg. No./Substance:
59-66-5/Acetazolamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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