| Arterial oxygen saturation during ascending to altitude under various conditions: lessons from the field. | |
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MedLine Citation:
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PMID: 17996494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When hypoxia increases during ascending in the mountains, ventilatory control and the related oxygenation may be challenged. The pre-treatment by intermittent hypoxia will elevate ventilation and offset hypoxemia and acetazolamide may inhibit peripheral chemosensitivity and act through central mechanisms. To study these effects in the field, one well-trained male mountaineer performed four ascents from low (1300m) to higher altitude (2600m): (1) under control conditions, (2) after intermittent hypoxia, (3) after pre-treatment with acetazolamide, and (4) after intermittent hypoxia+acetazolamide. When ascending under control conditions a cascading decrease of arterial oxygen saturation (SaO(2)) has been observed probably because of the alternating dominance of peripheral and central mechanisms of ventilatory control. While the pre-treatment with intermittent hypoxia prolonged the constant SaO(2) periods, the intake of acetazolamide eliminated this respiratory periodicity. Oxygen desaturation was best prevented by acetazolamide which was also associated with faster ascent times compared to control conditions. |
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Authors:
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Martin Burtscher |
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Publication Detail:
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Type: Journal Article Date: 2007-11-08 |
Journal Detail:
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Title: Journal of science and medicine in sport / Sports Medicine Australia Volume: 11 ISSN: 1440-2440 ISO Abbreviation: J Sci Med Sport Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-28 Completed Date: 2009-02-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812598 Medline TA: J Sci Med Sport Country: Australia |
Other Details:
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Languages: eng Pagination: 535-7 Citation Subset: IM |
Affiliation:
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Department of Sport Science, Medical Section, University of Innsbruck, Austria. Martin.Burtscher@uibk.ac.at |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetazolamide Altitude* Anoxia / physiopathology, prevention & control Arteries / metabolism* Exercise Test Humans Male Middle Aged Mountaineering Oxygen Consumption* |
| Chemical | |
Reg. No./Substance:
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59-66-5/Acetazolamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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