| Arterial lesions induced by phosphodiesterase III (PDE III) inhibitors and DA(1) agonists. | |
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MedLine Citation:
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PMID: 10720777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Compounds that inhibit the low Km, cGMP-inhibitable form of phosphodiesterase (type III) and the DA(1) agonist, fenoldopam, are potent vasodilators that have been associated with segmental medial haemorrhagic necrosis in susceptible arterial beds following administration of suprapharmacological doses to dogs and/or rats. Morphological and haemodynamic investigative studies with PDE III inhibitors support the hypothesis that the arterial toxicity is the consequence of the vasodilator pharmacology of these compounds. Investigative data also suggest that similar mechanisms are involved in the pathogenesis of arterial lesions induced by fenoldopam and the K(+) channel opener, minoxidil. |
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Authors:
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E C Joseph |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Toxicology letters Volume: 112-113 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-05-04 Completed Date: 2000-05-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 537-46 Citation Subset: IM |
Affiliation:
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Sanofi-Synthelabo Research Centre, Willowburn Avenue, Alnwick, Northumberland, UK. clive.joseph@sanofi-syhnthelabo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3',5'-Cyclic-AMP Phosphodiesterases
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antagonists & inhibitors* Animals Coronary Disease / chemically induced*, pathology Cyclic Nucleotide Phosphodiesterases, Type 3 Dogs Dopamine Agonists / toxicity* Fenoldopam / toxicity Hemodynamics / drug effects Mesenteric Arteries / drug effects*, pathology Minoxidil / toxicity Rats Vasodilator Agents / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Agonists; 0/Vasodilator Agents; 38304-91-5/Minoxidil; 67227-56-9/Fenoldopam; EC 3.1.4.17/3',5'-Cyclic-AMP Phosphodiesterases; EC 3.1.4.17/Cyclic Nucleotide Phosphodiesterases, Type 3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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