Document Detail


Arterial lesions in Behçet's disease.
MedLine Citation:
PMID:  12945099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Arterial involvement is a rare but serious condition in the course of Behçet's disease. We aimed to assess the results of therapeutic approaches in our patients with arterial lesions caused by Behçet's disease.
PATIENTS AND METHODS: The records of 534 patients with Behçet's disease between 1987 and 2002 were retrospectively evaluated for the presence of arterial lesions. All patients were followed up regularly at 3 to 6 months intervals.
RESULTS: Arterial lesions were diagnosed in 21 (3.9%) patients. Eight of these patients had pulmonary artery aneurysms (PAA), and the other 13 patients had non-pulmonary arterial lesions. Urgent surgical intervention was performed in three patients with PAA leading to death in all three. In addition, three other patients died due to massive haemoptysis at home despite to immunosuppressive therapy. Only two out of eight patients with PAA are still alive who were treated with cyclophophamide and corticosteroids. Thirteen operations were performed in 7 out of 13 patients having non-pulmonary arterial lesions. Although ten of the operations were primary operations, three reoperations had to be performed. A stent-graft was applied for the management of an iliac artery aneurysm in one patient. Only one patient died 8 years after the first non-pulmonary arterial involvement following a type IV thoracoabdominal aortic aneurysm repair. Five patients with arterial occlusive lesions were successfully treated by corticosteroids.
CONCLUSIONS: Pulmonary artery aneurysms in Behçet's disease patients have a poor prognosis despite any form of therapy. High dose corticosteroids alone can be successfully used for isolated non-pulmonary arterial occlusive lesions, unless disabling symptoms occur. Surgery or stent-graft insertion is indicated for non-pulmonary arterial aneurysms because these aneurysms entail high risk of complications.
Authors:
D Saba; H Saricaoğlu; A S Bayram; C Erdoğan; K Dilek; C Gebitekin; H Ozkan; Z G Ozer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  VASA. Zeitschrift für Gefässkrankheiten     Volume:  32     ISSN:  0301-1526     ISO Abbreviation:  VASA     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-08-29     Completed Date:  2003-12-29     Revised Date:  2012-10-19    
Medline Journal Info:
Nlm Unique ID:  0317051     Medline TA:  Vasa     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  75-81     Citation Subset:  IM    
Affiliation:
Uludağ University Medical Faculty, Department of Thoracic and Cardiovascular Surgery, Göğüs, Kalp ve Damar Cerrahisi Ana Bilim Dali, Görükle, 16059, Bursa, Turkey. davids@uludag.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Adult
Aneurysm / diagnosis*,  mortality,  surgery
Angiography, Digital Subtraction
Arterial Occlusive Diseases / diagnosis*,  mortality,  surgery
Behcet Syndrome / diagnosis*,  mortality,  surgery
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Pulmonary Artery / surgery
Retrospective Studies
Survival Rate
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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