Document Detail

Arterial lactate above 2 mM is associated with increased brain lactate and decreased brain glucose in patients with severe traumatic brain injury.
MedLine Citation:
PMID:  21971438     Owner:  NLM     Status:  Publisher    
BACKGROUND:Lactate fuels cerebral energy-consuming processes and is neuroprotective. The impact of arterial lactate on brain metabolism determined by microdialysis was investigated retrospectively in patients with severe traumatic brain injury (TBI). METHODS: Cerebral microdialysis (glucose, lactate), neuromonitoring (ICP, CPP, ptiO2, SjvO2) and blood gas data collected in 20 patients during pharmacologic coma were grouped within predefined arterial lactate clusters (<1, 1-1.9, ≥2 mM). Microdialysis samples were only taken from time points characterized by normoventilation (paCO2 4.6-5.6 kPa), sufficient oxygenation (paO2 >10 kPa) and hematocrit (≥24%) to exclude confounding influences. RESULTS: Elevated arterial lactate ≥2 mM was associated with significantly increased brain lactate which coincided with markedly decreased brain glucose despite significantly increased arterial glucose levels and sufficient cerebral perfusion indirectly determined by normal SjvO2 and ptiO2 values. At elevated arterial lactate levels signs of significantly increased cerebral lactate uptake coincided with markedly decreased cerebral glucose uptake. Infused lactate above 50 mM per 24 hours was associated with significantly decreased cerebral glucose. CONCLUSION:Increased arterial lactate levels were associated with increased cerebral lactate uptake and elevated brain lactate. At the same time brain glucose uptake and brain glucose were significantly reduced. It remains unclear whether arterial lactate is the driving force for the increased cerebral lactate levels or if the reduced glucose uptake also contributed to the increased cerebral lactate levels. Further studies are required to assess the impact of lactate infusion under clinical conditions.
R Meierhans; G Brandi; M Fasshauer; J Sommerfeld; R Schüpbach; M Béchir; J F Stover
Related Documents :
15599628 - Current outcome of elective open repair for infrarenal abdominal aortic aneurysm.
14656178 - Translumbar extraperitoneal decompression for abdominal compartment syndrome after endo...
17670408 - Systematic and exclusive use of intravascular ultrasound for endovascular aneurysm repa...
8889378 - Basic science of abdominal aortic aneurysms: emerging therapeutic strategies for an unr...
7100458 - Collateral circulation secondary to upper extremity venous thrombosis visualized during...
19165038 - The helical arcade: anatomic basis for survival in near-total ear avulsion.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-05
Journal Detail:
Title:  Minerva anestesiologica     Volume:  -     ISSN:  1827-1596     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375272     Medline TA:  Minerva Anestesiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Surgical Intensive Care, University Hospital Zürich, Zürich, Switzerland -
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Tramadol and 0.5% levobupivacaine for single-shot interscalene block: effects on postoperative analg...
Next Document:  Auto-PEEP in respiratory failure.