Document Detail

Arterial haemodynamics on ventricular hypertrophy in rats with simulated aortic stiffness.
MedLine Citation:
PMID:  17874128     Owner:  NLM     Status:  MEDLINE    
Aortic stiffness (AS) exerts significant impact on the cardiovascular risks. We developed a new model to produce AS. The purposes were to evaluate the haemodynamic consequence and to correlate the haemodynamic parameters with the extent of ventricular hypertrophy (VH). We applied silicon gel for embedding of the abdominal and/or thoracic aorta. After 1-4 weeks of AS, the left ventricular weight (LVW), LVW to body weight (BW) ratio (LVW/BW), and the morphological changes in cardiomyotes were quantified for VH. We determined the aortic pressure (AP), stroke volume, cardiac output, total peripheral resistance (TPR), characteristic impedance (Zc), pulse wave reflection (P(b)) and pulse wave velocity (PWV). Aortic embedding (AE) increased LVW, LVW/BW, systolic and pulse pressure (PP), Zc, P(b) and PWV accompanied by decreases in diastolic pressure and arterial compliance. The magnitude of these haemodynamic and cardiac changes were in an order of combined, thoracic and abdominal AE. Correlation analysis revealed that the VH was well correlated with pulsatile haemodynamics such as Zc, PP, P(b) and PWV, while less with steady components (Mean AP and TPR). Our results indicate that pulsatile haemodynamic parameters are significantly elevated after AS. The alterations in pulsatile haemodynamics are the major causes leading to VH.
Hsing I Chen; Nan-Kuang Hsieh; Huai-Ren Chang; Cheng-Tao Hu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-15
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  455     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-11-21     Completed Date:  2008-06-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  595-606     Citation Subset:  IM    
Institute of Integrative Physiology and Clinical Sciences, Tzu Chi University, No. 701, Sec. 3, Jhongyang Rd., Hualien 97004, Taiwan.
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MeSH Terms
Aorta / physiopathology*
Aortic Diseases / complications,  physiopathology*
Blood Flow Velocity
Blood Pressure
Cardiac Output
Disease Models, Animal
Hypertrophy, Left Ventricular / etiology*,  pathology,  physiopathology
Models, Cardiovascular
Pulsatile Flow
Rats, Sprague-Dawley
Regional Blood Flow
Stroke Volume
Vascular Resistance

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