| Arterial foci of F-18 fluorodeoxyglucose are associated with an enhanced risk of subsequent ischemic stroke in cancer patients: a case-control pilot study. | |
| | |
MedLine Citation:
|
PMID: 21220967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE OF THE REPORT: Imaging of F-18 fluorodeoxyglucose (FDG) by positron emission tomography/computed tomography (PET/CT) hybrid systems allows detecting arterial FDG foci, which relate to inflammatory and presumably unstable atherosclerosis, and is increasingly used in cancer patients among whom many are at risk for ischemic events. However, the link between an enhanced arterial FDG uptake and subsequent ischemic events remains to be clearly established. This pilot study aimed at determining whether the prior arterial FDG uptake in cancer patients presenting a subsequent stroke was higher than that of stroke-free controls. MATERIALS AND METHODS: Patients referred to FDG PET/CT for conventional oncologic indications were retrospectively included and compared between: (i) 7 case-patients with subsequent hospitalizations for documented ischemic stroke and (ii) 16 event-free controls, matched to the case-patients according to age, gender, and cancer site. RESULTS: Stroke was related with previous arterial FDG foci when detected on the aortic arch (stroke patients, 86% vs. Controls, 31%; P = 0.03) and especially on carotid bifurcations (stroke patients, 71% vs. Controls, 6%; P = 0.006); and among the 5 case-patients with stroke from carotid territory, 4 (80%) had FDG foci on ipsilateral carotid bifurcations. CONCLUSIONS: This pilot study shows that the previous detection of FDG foci on aortic arch and especially on carotid bifurcations of cancer patients is associated with the risk of subsequent ischemic stroke. A further confirmation on larger populations is needed. |
| | |
Authors:
|
Solène Grandpierre; Emmanuel Desandes; Benoit Meneroux; Wassila Djaballah; Damien Mandry; Fanny Netter; Denis Wahl; Renaud Fay; Gilles Karcher; Pierre-Yves Marie |
Related Documents
:
|
12096277 - Stent graft infection after abdominal aortic aneurysm repair: a case report. 2766137 - Omental pedicle grafting in the treatment of poststernotomy mediastinitis. 10758197 - Vascular clips in anastomoses of femoropopliteal arterial reconstruction. 8957397 - Dissection of the ascending aorta: a late complication of coronary artery bypass grafting. 3958337 - Prospective evaluation of the left main coronary artery using digital two-dimensional e... 16374677 - Catheter closure of perimembranous/membranous ventricular septal defects using the ampl... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical nuclear medicine Volume: 36 ISSN: 1536-0229 ISO Abbreviation: Clin Nucl Med Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-11 Completed Date: 2011-04-19 Revised Date: 2011-08-25 |
Medline Journal Info:
|
Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
|
Languages: eng Pagination: 85-90 Citation Subset: IM |
Affiliation:
|
Department of Nuclear Medicine, CHU-Nancy, F-54000, Nancy, France. solene.grandpierre@hotmail.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Arteries / metabolism Biological Transport Brain Ischemia / complications* Case-Control Studies Female Fluorodeoxyglucose F18 / diagnostic use, metabolism* Follow-Up Studies Humans Male Middle Aged Neoplasms / complications* Pilot Projects Positron-Emission Tomography Retrospective Studies Risk Stroke / complications*, metabolism*, radiography, radionuclide imaging Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
|
63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: GDNF/Ret signaling and renal branching morphogenesis: From mesenchymal signals to epithelial cell be...
Next Document: Utility of ¹¹C-choline imaging as a supplement to F-18 FDG PET imaging for detection of thyroid ca...