Document Detail


Arterial foci of F-18 fluorodeoxyglucose are associated with an enhanced risk of subsequent ischemic stroke in cancer patients: a case-control pilot study.
MedLine Citation:
PMID:  21220967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF THE REPORT: Imaging of F-18 fluorodeoxyglucose (FDG) by positron emission tomography/computed tomography (PET/CT) hybrid systems allows detecting arterial FDG foci, which relate to inflammatory and presumably unstable atherosclerosis, and is increasingly used in cancer patients among whom many are at risk for ischemic events. However, the link between an enhanced arterial FDG uptake and subsequent ischemic events remains to be clearly established. This pilot study aimed at determining whether the prior arterial FDG uptake in cancer patients presenting a subsequent stroke was higher than that of stroke-free controls.
MATERIALS AND METHODS: Patients referred to FDG PET/CT for conventional oncologic indications were retrospectively included and compared between: (i) 7 case-patients with subsequent hospitalizations for documented ischemic stroke and (ii) 16 event-free controls, matched to the case-patients according to age, gender, and cancer site.
RESULTS: Stroke was related with previous arterial FDG foci when detected on the aortic arch (stroke patients, 86% vs. Controls, 31%; P = 0.03) and especially on carotid bifurcations (stroke patients, 71% vs. Controls, 6%; P = 0.006); and among the 5 case-patients with stroke from carotid territory, 4 (80%) had FDG foci on ipsilateral carotid bifurcations.
CONCLUSIONS: This pilot study shows that the previous detection of FDG foci on aortic arch and especially on carotid bifurcations of cancer patients is associated with the risk of subsequent ischemic stroke. A further confirmation on larger populations is needed.
Authors:
Solène Grandpierre; Emmanuel Desandes; Benoit Meneroux; Wassila Djaballah; Damien Mandry; Fanny Netter; Denis Wahl; Renaud Fay; Gilles Karcher; Pierre-Yves Marie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  36     ISSN:  1536-0229     ISO Abbreviation:  Clin Nucl Med     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-11     Completed Date:  2011-04-19     Revised Date:  2011-08-25    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-90     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, CHU-Nancy, F-54000, Nancy, France. solene.grandpierre@hotmail.fr
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MeSH Terms
Descriptor/Qualifier:
Aged
Arteries / metabolism
Biological Transport
Brain Ischemia / complications*
Case-Control Studies
Female
Fluorodeoxyglucose F18 / diagnostic use,  metabolism*
Follow-Up Studies
Humans
Male
Middle Aged
Neoplasms / complications*
Pilot Projects
Positron-Emission Tomography
Retrospective Studies
Risk
Stroke / complications*,  metabolism*,  radiography,  radionuclide imaging
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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