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ARTERIAL ERECTILE DYSFUNCTION AND PERIPHERAL ARTERIAL DISEASE: RELIABILITY OF A NEW PHENOTYPE OF ENDOTHELIAL PROGENITOR CELLS AND ENDOTHELIAL MICROPARTICLES.
MedLine Citation:
PMID:  22362078     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Introduction. Aim of this study was to evaluate whether the blood concentrations of a new immunophenotype of circulating late endothelial progenitor cells (EPCs) and endothelial microparticles (EMPs) varies in patients with arterial erectile dysfunction (aED) and abnormalities in other arterial districts. Materials and methods. To accomplish this, cavernous artery peak systolic velocity (PSV), acceleration time (AT) and intima media-thickness (IMT) were determined after intracavernous administration of alprostadil by echo-color Doppler in 80 consecutive patients (age range: 50-75 years). Fifteen patients had aED alone (group A) and served as controls; 22 had aED plus atheroma plaques and/or increased intima-media thickness of the common carotid artery (group B); 20 had aED plus lower limb artery abnormalities (group C); and 23 had aED plus carotid and lower limb artery abnormalities (group D). EPCs and EMPs blood concentrations were evaluated by flow cytometry. Blood mononuclear cells with the following immunophenotye CD45neg/CD34pos/CD144pos were defined EPCs, whereas CD45neg/CD144pos/Annexin Vpos cells were defined EMPs. Results. Group B and C patients had a similar PSV, AT, and IMT at the level of the cavernous arteries. Their PSV was significantly lower and mean values of AT and IMT significantly higher compared with group A patients. Patients of the group D had a significantly lower PSV and significantly higher AT and IMT compared with all other groups. As far as serum concentrations of EPCs and EMPs, group D patients had a significantly higher EPC and EMP mean values compared with all other groups. Group B and C patients had similar EPCs and EMPs values. Conclusions. This study showed that a more generalized peripheral atherosclerotic process is associated with a more severe penile artery insufficiency and endothelial dysfunction. Moreover, this study confirms the diagnostic reliability of the immunophenotype of EPCs and EMPs chosen in the clinical practice.
Authors:
Rosita Condorelli; Aldo Calogero; Enzo Vicari; Luigi Di Pino; Filippo Giacone; Laura Mongioì; Sandro La Vignera
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-23
Journal Detail:
Title:  Journal of andrology     Volume:  -     ISSN:  1939-4640     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106453     Medline TA:  J Androl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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