Document Detail


Arterial enlargement in the atherosclerosis risk in communities (ARIC) cohort. In vivo quantification of carotid arterial enlargement. The ARIC Investigators.
MedLine Citation:
PMID:  8023349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: The relation between arterial wall (intimal-medial) thickness and lumen narrowing is complex and has previously been studied predominantly at autopsy. B-mode ultrasound affords the opportunity to visualize both wall and lumen of the extracranial carotid arteries in vivo. Several studies have quantified the relation of various independent variables to wall thickness of carotid arteries in population-based samples, but the relation of age and wall thickness to interadventitial and lumen diameter has not previously been investigated in these samples. METHODS: We used B-mode ultrasound to quantify the relation of arterial lumen diameter to age, arterial wall thickness, and arterial size (interadventitial diameter) of the extracranial carotid artery in 13,711 members of the Atherosclerosis Risk in Communities (ARIC) cohort. RESULTS: Men had greater interadventitial diameters, thicker walls, and wider lumens than women. Wall thicknesses of the common carotid artery were greater by 21% in men and 22% in women aged 60 to 64 years compared with those aged 45 to 49 years (P < .001). However, lumen diameters were also greater in older individuals because interadventitial diameters were greater. Wall thickness of the internal carotid artery was also associated positively with age, but the lumen diameter of the internal carotid artery was smaller in older individuals. Diameters of the carotid artery segments also differed in their relation to arterial wall thickening. The lumen of the internal carotid artery was uniformly progressively narrower with increasing wall thickness. For the common carotid artery greater wall thickness bore only a small correlation with narrower lumen diameter for thickening of the arterial wall up to 1.2 mm, but the association was more marked for the range of thicknesses between 1.2 mm and 2.5 mm. CONCLUSIONS: When arterial enlargement accompanies increased wall thickness, less lumen constriction results than expected. Quantification of these complex relations in vivo may provide new insight into the pathogenesis of symptoms related to vascular disease. Narrowing of the internal carotid artery lumen associated with thicker walls is consistent with the observation that stenosis develops in this region and often leads to symptoms.
Authors:
J R Crouse; U Goldbourt; G Evans; J Pinsky; A R Sharrett; P Sorlie; W Riley; G Heiss
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  25     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-07-29     Completed Date:  1994-07-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1354-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Arteriosclerosis / epidemiology,  ultrasonography*
Carotid Artery Diseases / ultrasonography*
Carotid Artery, Common / ultrasonography
Carotid Artery, Internal / ultrasonography
Cohort Studies
Female
Humans
Male
Middle Aged
Risk Factors
Sex Factors
Grant Support
ID/Acronym/Agency:
NHLBI NO1-HC-55015/HC/NHLBI NIH HHS; NHLBI NO1-HC-55016/HC/NHLBI NIH HHS; NHLBI NO1-HC-55018/HC/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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