| Arterial enhancement of hepatocellular carcinoma before radiofrequency ablation as a predictor of postablation local tumor progression. | |
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MedLine Citation:
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PMID: 19696290 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of our study was to elucidate whether the degree of arterial enhancement on CT is a significant risk factor for local tumor progression after percutaneous radiofrequency ablation of hepatocellular carcinomas (HCCs) larger than 2 cm. MATERIALS AND METHODS: Percutaneous radiofrequency ablation procedures to treat 203 previously untreated HCCs larger than 2 cm in 190 patients were analyzed retrospectively. We assessed the technique effectiveness rate 1 month after the procedure and the cumulative local tumor progression rate. The tumors were classified into one of the following groups for qualitative analysis: group with evident contrast enhancement or group showing subtle or no contrast enhancement. We performed quantitative analysis of increments in the attenuation (in Hounsfield units [HU]) from unenhanced to arterial phase CT of the 78 HCCs for which unenhanced CT was available. To determine any significant risk factor, various factors, including the degree of arterial enhancement, were tested by multivariate analysis. RESULTS: The technique effectiveness rate was 99.0% (201/203). Local tumor progression was detected in 23.9% (48/201), and the cumulative rates of local tumor progression at 1, 2, and 3 years were 12.9%, 23.1%, and 27.6%, respectively. The two qualitative groups were significantly different in their cumulative local tumor progression rates (p = 0.009). Multivariate analysis revealed that the degree of arterial enhancement was a sole independent significant risk factor for local tumor progression (p = 0.026). CONCLUSION: A high degree of arterial enhancement on CT after percutaneous radiofrequency ablation of HCCs larger than 2 cm is a significant risk factor for local tumor progression. |
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Authors:
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Yulri Park; Young-Sun Kim; Hyunchul Rhim; Hyo Keun Lim; Dongil Choi; Won Jae Lee |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: AJR. American journal of roentgenology Volume: 193 ISSN: 1546-3141 ISO Abbreviation: AJR Am J Roentgenol Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-21 Completed Date: 2009-09-29 Revised Date: 2010-04-21 |
Medline Journal Info:
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Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: United States |
Other Details:
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Languages: eng Pagination: 757-63 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, Center for Imaging Science, Samsung Medical Center, Sunkyunkwan University School of Medicine, [corrected] 50, Ilwon-dong, Gangnam-gu, Seoul 135-710, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arteries Carcinoma, Hepatocellular / blood supply, pathology, radiography*, surgery* Catheter Ablation* Contrast Media / administration & dosage Disease Progression Female Humans Iohexol / administration & dosage, analogs & derivatives Liver Neoplasms / blood supply, pathology, radiography*, surgery* Male Middle Aged Multivariate Analysis Radiographic Image Interpretation, Computer-Assisted Retrospective Studies Risk Factors Tomography, X-Ray Computed / methods* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 66108-95-0/Iohexol; 73334-07-3/iopromide |
| Comments/Corrections | |
Erratum In:
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AJR Am J Roentgenol. 2010 May;194(5):1404 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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