Document Detail

Arterial elasticity among normotensive subjects and treated and untreated hypertensive subjects.
MedLine Citation:
PMID:  12055417     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to determine arterial elasticity in normotensive and hypertensive individuals. BACKGROUND: In addition to blood pressure, other parameters serve as markers for vascular disease. Arterial elasticity is one parameter that can be determined by a modified Windkessel model of the circulation. This model estimates, from a computerized pulse contour analysis, the proximal (capacitive) elasticity of the large arteries and the distal (reflective) elasticity of the small arteries. METHODS: A prospective, multi-center, controlled clinical study evaluated large-artery and small-artery elasticity indices in four groups: (1) normotensives without a family history of hypertension; (2) normotensives with a family history of hypertension; (3) treated and controlled hypertensives; and (4) untreated and uncontrolled hypertensives. Blood pressure, using a mercury manometer, and arterial elasticity, using a CVProfilor DO-2020 CardioVascular Profiling System (Hypertension Diagnostics, Inc., Eagan, MN, USA), were measured supine in triplicate 3 min apart in a randomized sequence. RESULTS: There were 212 evaluable subjects of mean age 46 years; 57% were women, 51% Caucasian and 33% African-American. Comparing normotensives without a family history and untreated hypertensives, both large-artery and small-artery elasticity indices were significantly different (P < 0.0001). After controlling for age and body surface area, a significant linear trend (P = 0.0001) across the four groups was detected for both large- and small-artery elasticity indices. CONCLUSION: As the hypertension status worsened, large- and small-artery elasticity indices decreased, suggesting a potential for the diagnostic use of arterial elasticity determinations.
L M Prisant; L M Resnick; S M Hollenberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood pressure monitoring     Volume:  6     ISSN:  1359-5237     ISO Abbreviation:  Blood Press Monit     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2002-06-10     Completed Date:  2003-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9606438     Medline TA:  Blood Press Monit     Country:  England    
Other Details:
Languages:  eng     Pagination:  233-7     Citation Subset:  IM    
Hypertension Unit, Section of Cardiology, Medical College of Georgia, Augusta 30912-3105, USA.
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MeSH Terms
Arteries / physiology*
Cardiovascular Diseases / diagnosis*,  physiopathology
Case-Control Studies
Continental Population Groups
Disease Progression
Family Health
Hypertension / physiopathology*
Middle Aged
Models, Cardiovascular
Prospective Studies

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