Document Detail


Arterial disease in chronic kidney disease.
MedLine Citation:
PMID:  23118349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
End stage renal disease is associated with a very high risk of premature cardiovascular death and morbidity. Early stage chronic kidney disease (CKD) is also associated with an increased frequency of cardiovascular events and is a common but poorly recognised and undertreated risk factor. Cardiovascular disease in CKD can be attributed to two distinct but overlapping pathological processes, namely atherosclerosis and arteriosclerosis. While the risk of athero-thrombotic events such as myocardial infarction is elevated, arteriosclerosis is the predominant pathophysiological process involving fibrosis and thickening of the medial arterial layer. This results in increased arterial stiffness causing left ventricular hypertrophy and fibrosis and the exposure of vulnerable vascular beds such as the brain and kidney to high pressure fluctuations causing small vessel disease. These pathophysiological features are manifest by a high risk of lethal arrhythmia, congestive heart failure, myocardial infarction and stroke. Recent work has highlighted the importance of aldosterone and disordered bone mineral metabolism.
Authors:
William E Moody; Nicola C Edwards; Colin D Chue; Charles J Ferro; Jonathan N Townend
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-10-31
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  99     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-20     Completed Date:  2013-04-11     Revised Date:  2014-03-14    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  365-72     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Arterial Occlusive Diseases* / diagnosis,  epidemiology,  etiology
Diagnostic Imaging
Disease Progression
Humans
Incidence
Renal Insufficiency, Chronic / complications*,  physiopathology
Risk Factors
World Health
Grant Support
ID/Acronym/Agency:
FS/11/17/28700//British Heart Foundation; PB-PG-0110-21226//Department of Health; PDF-2012-05-205//Department of Health; PG/12/35/29403//British Heart Foundation; //British Heart Foundation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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