Document Detail

Arterial complications following cardiac catheterization in children less than 10 kg.
MedLine Citation:
PMID:  12079935     Owner:  NLM     Status:  MEDLINE    
We sought to determine if a higher dose of heparin would reduce arterial complications in patients weighing 10 kg or less undergoing cardiac catheterization to investigate congenital heart disease. Sixty patients were given either 100 (group A) or 150 (group B) IU x kg(-1) of heparin in a double-blinded randomized manner. Initial arterial access was established using a 4F cannula in all patients. Mean activated clotting time measured 20 minutes following heparin administration was significantly lower in group A than in group B (199 versus 251 seconds). Only 3 out of 60 patients (5%) required treatment for loss of femoral pulse. The age, weight, activated clotting time, length of catheterization procedure, time taken to establish arterial access, and the duration of arterial cannulation were comparable between the groups. Weight under 4 kg, age under 1 month, and cannula size larger than 4F were identified as independent risk factors for the development of arterial complications. Arterial access using a 4F cannula is a safe procedure in children weighing 10 kg or less. The incidence of significant arterial complications is low, and they do not appear to be preventable by a higher dose of heparin.
Ziad R Bulbul; Mohammed Omar Galal; Elsayed Mahmoud; Bettina Narden; Laszlo Solymar; Mohammad Ashraf Chaudhary; Zohair Y Al Halees
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Asian cardiovascular & thoracic annals     Volume:  10     ISSN:  0218-4923     ISO Abbreviation:  Asian Cardiovasc Thorac Ann     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-24     Completed Date:  2002-09-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9503417     Medline TA:  Asian Cardiovasc Thorac Ann     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  129-32     Citation Subset:  IM    
Department of Cardiovascular Diseases, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
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MeSH Terms
Anticoagulants / administration & dosage*,  therapeutic use
Body Weight
Double-Blind Method
Heart Catheterization / adverse effects*
Heart Defects, Congenital / diagnosis*
Heparin / administration & dosage*,  therapeutic use
Logistic Models
Partial Thromboplastin Time
Risk Factors
Thrombosis / etiology,  prevention & control*
Reg. No./Substance:
0/Anticoagulants; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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