| Arterial cerebrovascular complications in 94 adults with acute bacterial meningitis. | |
| | |
MedLine Citation:
|
PMID: 22112693 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
ABSTRACT: INTRODUCTION: Intracranial vascular complications are an important complication of acute bacterial meningitis. Ischemic stroke in meningitis is reported as a result of vasculitis, vasospasm, endocarditis or intraarterial thrombosis. The aim of the study was to identify the value of measuring cerebral blood flow velocity (CBFv) on transracranial doppler (TCD) in the identification of patients at risk for meningitis-associated stroke. METHOD: We retrospectively studied patients with acute bacterial meningitis who were treated in our university hospital from 2000 to 2009. Data were analyzed with the main focus on the incidence of an increase of CBFv on TCD, defined as peak systolic values above 150 cm/s, and the development of stroke. RESULTS: In total, 114 patients with acute bacterial meningitis were treated, 94 of them received routine TCD studies during their hospital stay. 41/94 patients had elevated CBFv values. This increase was associated with an increased risk of stroke (odds ratio (95% confidence intervall) = 9.15 (1.96-42.67); p < 0.001) and unfavorable outcome (Glasgow Outcome Score < 4; odds ratio (95% confidence intervall) = 2.93 (1.23-6.98); p = 0.018). 11/32 (34.4%) patients with an increase of CBFv who received nimodipine and 2/9 (22.2%) patients with an increase of CBFv who did not receive nimodipine developed stroke (p=0.69). CONCLUSIONS: In summary, TCD was found to be a valuable bedside test to detect arterial alterations in patients with bacterial meningitis. These patients have an increased risk of stroke. |
| | |
Authors:
|
Matthias Klein; Uwe Koedel; Thomas Pfefferkorn; Grete Zeller; Bianca Woehrl; Hans-Walter Pfister |
Related Documents
:
|
10713013 - Predicting the result of noninvasive ventilation in severe acute exacerbations of patie... 7656633 - Indicators of need for mechanical ventilation in duchenne muscular dystrophy and spinal... 17895123 - The clomethiazole acute stroke study in ischemic, hemorrhagic, and t-pa treated stroke:... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-23 |
Journal Detail:
|
Title: Critical care (London, England) Volume: 15 ISSN: 1466-609X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9801902 Medline TA: Crit Care Country: - |
Other Details:
|
Languages: ENG Pagination: R281 Citation Subset: - |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Polycomb genes and cancer: Time for clinical application?
Next Document: Prolonged ventilation post cardiac surgery - tips and pitfalls of the prediction game.