Document Detail


Arterial calcification in race horses.
MedLine Citation:
PMID:  18725464     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Calcification of large arteries has been sporadically reported in horses. The pathogenesis is still unknown, but recent studies in humans suggest that this is a regulated biomineralizing process. This study surveyed the prevalence, distribution, and severity of vascular calcification in Thoroughbred and Standardbred racehorses. Histopathologic, ultrastructural imaging, and energy dispersive X-ray elemental analyses were used to examine the lesions. Calcification of the tunica media, predominantly the pulmonary artery, was found in 82% of horses (83/101). Young adult horses (mean [SD] age in years, 4.44 +/- 2.17) of both breeds and sexes were similarly affected. Lesions appeared as white-to-yellowish, hard, and gritty plaques of variable size. On microscopic examination, elastic fibers within the tunica media were thinned, fragmented, and calcified, and surrounded by dense collagen matrix. Elemental analysis showed distinct peaks for calcium and phosphorus, consistent with hydroxyapatite mineral. The frequent occurrence of calcification in the tunica media of large pulmonary arteries of young racing horses indicates the need to investigate its pathogenesis and potential clinical implications.
Authors:
L G Arroyo; M A Hayes; J Delay; C Rao; B Duncan; L Viel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary pathology     Volume:  45     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-26     Completed Date:  2008-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  617-25     Citation Subset:  IM    
Affiliation:
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1 (Canada). larroyo@uoguelph.ca
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Arteries / pathology*,  ultrastructure
Calcinosis / pathology,  veterinary*
Female
Histocytochemistry / veterinary
Horse Diseases / epidemiology,  metabolism,  pathology*
Horses
Logistic Models
Male
Microscopy, Electron, Scanning / veterinary
Microscopy, Electron, Transmission
Ontario / epidemiology
Prevalence
Vascular Diseases / epidemiology,  pathology,  veterinary*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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