Document Detail

Arterial calcification: cardiovascular function and clinical outcome.
MedLine Citation:
PMID:  22130278     Owner:  NLM     Status:  MEDLINE    
Arterial calcification (AC) is a common complication of CKD and ESRD, and the extents of AC are predictive of subsequent cardiovascular mortality beyond established conventional risk factors. AC develop in two distinct sites: the intima and media layers of the large and medium-sized arterial wall. These two forms are frequently associated. AC is tightly associated with aging and arterial remodeling, including intima-media thickening, but also changes of the geometry and function of aortic valves. Evidence has accumulated pointing to the active and regulated nature of the calcification process. Elevated phosphate and calcium may stimulate sodium–dependent phosphate cotransport involving osteoblast–like changes in cellular gene expression. AC is responsible for stiffening of the arteries with increased left ventricular afterload and abnormal coronary perfusion as the principal clinical consequences.
G M London
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nefrología : publicación oficial de la Sociedad Española Nefrologia     Volume:  31     ISSN:  1989-2284     ISO Abbreviation:  Nefrologia     Publication Date:  2011  
Date Detail:
Created Date:  2011-12-01     Completed Date:  2012-04-24     Revised Date:  2012-08-20    
Medline Journal Info:
Nlm Unique ID:  8301215     Medline TA:  Nefrologia     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  644-7     Citation Subset:  IM    
INSERM U970, Paris and Hopital F.H. Manhès, Fleury-Mérogis, France.
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MeSH Terms
Arterial Occlusive Diseases / drug therapy,  etiology,  metabolism,  physiopathology*,  prevention & control
Atherosclerosis / complications*,  pathology
Calcinosis / drug therapy,  etiology,  metabolism,  physiopathology*,  prevention & control
Calcium / metabolism
Cell Differentiation
Chronic Disease
Core Binding Factor Alpha 1 Subunit / physiology
Gene Expression Regulation
Kidney Diseases / complications*,  therapy
Kidney Failure, Chronic / complications,  therapy
Muscle, Smooth, Vascular / pathology
Osteoblasts / pathology
Phosphates / metabolism
Transcription Factors / physiology
Tunica Intima / pathology
Tunica Media / pathology
Vascular Resistance
Ventricular Dysfunction, Left / etiology*,  physiopathology
Reg. No./Substance:
0/Core Binding Factor Alpha 1 Subunit; 0/Phosphates; 0/RUNX2 protein, human; 0/Sp7 protein, human; 0/Transcription Factors; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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