| Arterial calcification: cardiovascular function and clinical outcome. | |
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MedLine Citation:
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PMID: 22130278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arterial calcification (AC) is a common complication of CKD and ESRD, and the extents of AC are predictive of subsequent cardiovascular mortality beyond established conventional risk factors. AC develop in two distinct sites: the intima and media layers of the large and medium-sized arterial wall. These two forms are frequently associated. AC is tightly associated with aging and arterial remodeling, including intima-media thickening, but also changes of the geometry and function of aortic valves. Evidence has accumulated pointing to the active and regulated nature of the calcification process. Elevated phosphate and calcium may stimulate sodium–dependent phosphate cotransport involving osteoblast–like changes in cellular gene expression. AC is responsible for stiffening of the arteries with increased left ventricular afterload and abnormal coronary perfusion as the principal clinical consequences. |
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Authors:
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G M London |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Nefrología : publicación oficial de la Sociedad Española Nefrologia Volume: 31 ISSN: 1989-2284 ISO Abbreviation: Nefrologia Publication Date: 2011 |
Date Detail:
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Created Date: 2011-12-01 Completed Date: 2012-04-24 Revised Date: 2012-08-20 |
Medline Journal Info:
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Nlm Unique ID: 8301215 Medline TA: Nefrologia Country: Spain |
Other Details:
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Languages: eng Pagination: 644-7 Citation Subset: IM |
Affiliation:
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INSERM U970, Paris and Hopital F.H. Manhès, Fleury-Mérogis, France. glondon@club-internet.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arterial Occlusive Diseases
/
drug therapy,
etiology,
metabolism,
physiopathology*,
prevention & control Atherosclerosis / complications*, pathology Calcinosis / drug therapy, etiology, metabolism, physiopathology*, prevention & control Calcium / metabolism Cell Differentiation Chronic Disease Core Binding Factor Alpha 1 Subunit / physiology Gene Expression Regulation Humans Kidney Diseases / complications*, therapy Kidney Failure, Chronic / complications, therapy Muscle, Smooth, Vascular / pathology Osteoblasts / pathology Phosphates / metabolism Transcription Factors / physiology Tunica Intima / pathology Tunica Media / pathology Vascular Resistance Ventricular Dysfunction, Left / etiology*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Core Binding Factor Alpha 1 Subunit; 0/Phosphates; 0/RUNX2 protein, human; 0/Sp7 protein, human; 0/Transcription Factors; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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