Document Detail

Arterial calcification as a marker for atherosclerosis in three Arctic populations.
MedLine Citation:
PMID:  10093295     Owner:  NLM     Status:  MEDLINE    
Accumulation of calcification in the arterial wall in the course of the atherogenic process is considered to be a manifestation of advanced atherosclerosis. In this study of autopsy specimens from Alaska non-Natives, Alaska Natives, and Greenland Natives, comparisons were made of the prevalence and extent of arterial calcification with that of all raised (advanced) lesions in the thoracic aorta, abdominal aorta, right coronary artery, and left anterior descending coronary artery, to determine the degree to which calcified lesions track the development of advanced lesions. Calcification was determined quantitatively from radiograph images of the fixed specimens; advanced lesion data on these specimens were available from prior studies. Findings show that the prevalence and extent of calcified lesions closely follows the pattern of prevalence and extent of advanced lesions among the groups. We conclude that calcification is a good marker for comparisons of the prevalence and may also provide a good measure of the extent of atherosclerosis in these populations.
D Troxclair; D A Boudreau; G T Malcom; H S Pedersen; G Mulvad; W P Newmann; J P Middaugh
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of circumpolar health     Volume:  57 Suppl 1     ISSN:  1239-9736     ISO Abbreviation:  Int J Circumpolar Health     Publication Date:  1998  
Date Detail:
Created Date:  1999-05-20     Completed Date:  1999-05-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9713056     Medline TA:  Int J Circumpolar Health     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  306-11     Citation Subset:  IM    
Department of Pathology, Louisiana State University Medical Center, New Orleans, USA.
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MeSH Terms
Age Distribution
Aged, 80 and over
Alaska / epidemiology
Arctic Regions / epidemiology
Arteries / pathology*
Arteriosclerosis / epidemiology,  pathology*
Biological Markers / analysis
Calcinosis / epidemiology,  pathology*,  radiography
Culture Techniques
Ethnic Groups / statistics & numerical data
Greenland / epidemiology
Image Processing, Computer-Assisted
Middle Aged
Sensitivity and Specificity
Severity of Illness Index
Sex Distribution
Grant Support
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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