| Arterial calcification as a marker for atherosclerosis in three Arctic populations. | |
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MedLine Citation:
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PMID: 10093295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Accumulation of calcification in the arterial wall in the course of the atherogenic process is considered to be a manifestation of advanced atherosclerosis. In this study of autopsy specimens from Alaska non-Natives, Alaska Natives, and Greenland Natives, comparisons were made of the prevalence and extent of arterial calcification with that of all raised (advanced) lesions in the thoracic aorta, abdominal aorta, right coronary artery, and left anterior descending coronary artery, to determine the degree to which calcified lesions track the development of advanced lesions. Calcification was determined quantitatively from radiograph images of the fixed specimens; advanced lesion data on these specimens were available from prior studies. Findings show that the prevalence and extent of calcified lesions closely follows the pattern of prevalence and extent of advanced lesions among the groups. We conclude that calcification is a good marker for comparisons of the prevalence and may also provide a good measure of the extent of atherosclerosis in these populations. |
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Authors:
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D Troxclair; D A Boudreau; G T Malcom; H S Pedersen; G Mulvad; W P Newmann; J P Middaugh |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: International journal of circumpolar health Volume: 57 Suppl 1 ISSN: 1239-9736 ISO Abbreviation: Int J Circumpolar Health Publication Date: 1998 |
Date Detail:
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Created Date: 1999-05-20 Completed Date: 1999-05-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9713056 Medline TA: Int J Circumpolar Health Country: FINLAND |
Other Details:
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Languages: eng Pagination: 306-11 Citation Subset: IM |
Affiliation:
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Department of Pathology, Louisiana State University Medical Center, New Orleans, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Distribution Aged Aged, 80 and over Alaska / epidemiology Angiography Arctic Regions / epidemiology Arteries / pathology* Arteriosclerosis / epidemiology, pathology* Autopsy Biological Markers / analysis Calcinosis / epidemiology, pathology*, radiography Child Culture Techniques Ethnic Groups / statistics & numerical data Female Greenland / epidemiology Humans Image Processing, Computer-Assisted Male Middle Aged Prevalence Sensitivity and Specificity Severity of Illness Index Sex Distribution |
| Grant Support | |
ID/Acronym/Agency:
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HL-42082/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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