Document Detail


Arterial blood pressure and heart rate changes during self-stimulation by dogs in the basal forebrain region, lateral preoptic area, hypothalamus, ventral midbrain and amygdala.
MedLine Citation:
PMID:  501665     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In dogs pressing a lever for a brain-stimulation reward, arterial blood pressure (ABP) was elevated for 20 out of 24 sites tested, but this effect was usually conspicuous only at twice the threshold current sustaining stable performance. Hypertension was seen only in one ventral tegmental and two hypothalamic sites. In three anterior placements the ABP and heart rate (HR) increased more upon a fixed ratio than on continuous reinforcement. In most sites, self-stimulation was accompanied by cardiac acceleration; however, in some placements the HR was similar to or even less than control values. Continuous stimulation (5-10 sec) at one nucleus accumbens and four hypothalamic sites by the experimenter was aversive and produced a clearcut pressor response. The cardiovascular changes seem to depend on a spread of current to brain centres controlling circulatory functions and also, to some extent, on the animal's motor activity. The results contradict the claim that a causal relationship exists between the autonomic concomitants of self-stimulation and the intrinsic nature of the brain-stimulation reward.
Authors:
B Sadowski; A Wauquier; A Jageneau; P A Janssen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal de physiologie     Volume:  75     ISSN:  0021-7948     ISO Abbreviation:  J. Physiol. (Paris)     Publication Date:  1979  
Date Detail:
Created Date:  1980-01-24     Completed Date:  1980-01-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9309350     Medline TA:  J Physiol (Paris)     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  255-67     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amygdala / physiology
Animals
Blood Pressure*
Brain / physiology*
Diastole
Dogs
Heart Rate*
Hypothalamus / physiology
Mesencephalon / physiology
Preoptic Area / physiology
Self Stimulation / physiology*
Systole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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